Michael A Trembley
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Explore the profile of Michael A Trembley including associated specialties, affiliations and a list of published articles.
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22
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534
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Recent Articles
1.
Sweat M, Shi W, Keating E, Ponek A, Li J, Ma Q, et al.
bioRxiv
. 2024 Dec;
PMID: 39677667
Atrial fibrillation (AF) is the most common sustained arrhythmia, affecting 59 million individuals worldwide. Impairment of atrial cardiomyocyte (aCM) gene regulatory mechanisms predisposes to atrial fibrillation. The transcription factor TBX5...
2.
Lu F, Liou C, Ma Q, Wu Z, Xue B, Xia Y, et al.
Nat Biomed Eng
. 2024 Sep;
PMID: 39237710
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) lack nanoscale structures essential for efficient excitation-contraction coupling. Such nanostructures, known as dyads, are frequently disrupted in heart failure. Here we...
3.
Sweat M, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Kulandaisamy A, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(11):1095.
PMID: 39196102
No abstract available.
4.
Bortolin R, Nawar F, Park C, Trembley M, Prondzynski M, Sweat M, et al.
Circulation
. 2024 Aug;
150(15):1199-1210.
PMID: 39155863
Background: Calmodulinopathies are rare inherited arrhythmia syndromes caused by dominant heterozygous variants in , , or , which each encode the identical CaM (calmodulin) protein. We hypothesized that antisense oligonucleotide...
5.
Prondzynski M, Berkson P, Trembley M, Tharani Y, Shani K, Bortolin R, et al.
Nat Commun
. 2024 Jul;
15(1):5929.
PMID: 39009604
Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. Challenges with quality, inter-batch consistency, cryopreservation and scale remain, reducing experimental reproducibility and clinical translation. Here, we...
6.
Prondzynski M, Bortolin R, Berkson P, Trembley M, Shani K, Sweat M, et al.
bioRxiv
. 2024 Mar;
PMID: 38464269
In the last decade human iPSC-derived cardiomyocytes (hiPSC-CMs) proved to be valuable for cardiac disease modeling and cardiac regeneration, yet challenges with scale, quality, inter-batch consistency, and cryopreservation remain, reducing...
7.
Chen J, Zhang X, DeLaughter D, Trembley M, Saifee S, Xiao F, et al.
Circ Res
. 2024 Feb;
134(5):529-546.
PMID: 38348657
Background: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and lymphatic). How this heterogeneity is established...
8.
Sweat M, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Arulsamy K, et al.
Nat Cardiovasc Res
. 2024 Feb;
2(10):881-898.
PMID: 38344303
Understanding how the atrial and ventricular heart chambers maintain distinct identities is a prerequisite for treating chamber-specific diseases. Here, we selectively knocked out (KO) the transcription factor in the atrial...
9.
Kim S, Trembley M, Lee K, Choi S, MacQueen L, Zimmerman J, et al.
Stem Cell Reports
. 2023 Aug;
18(9):1811-1826.
PMID: 37595583
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes life-threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 (PKP2), a desmosome component within specialized cardiac cell junctions, cause the...
10.
Sweat M, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg B, et al.
bioRxiv
. 2023 May;
PMID: 37131696
Understanding how the atrial and ventricular chambers of the heart maintain their distinct identity is a prerequisite for treating chamber-specific diseases. Here, we selectively inactivated the transcription factor in the...