Michael A Pontikos
Overview
Explore the profile of Michael A Pontikos including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
59
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0
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Recent Articles
1.
Pontikos M, Leija C, Zhao Z, Wang X, Kilgore J, Tornesi B, et al.
Biochem Pharmacol
. 2022 Sep;
204:115237.
PMID: 36055381
Dihydroorotate dehydrogenase (DHODH) catalyzes a key step in pyrimidine biosynthesis and has recently been validated as a therapeutic target for malaria through clinical studies on the triazolopyrimidine-based Plasmodium DHODH inhibitor...
2.
Chan W, Horvath T, Tan L, Link T, Harutyunyan K, Pontikos M, et al.
Mol Cancer Ther
. 2019 Jun;
18(9):1587-1592.
PMID: 31209181
We and others have reported that the anticancer activity of L-asparaginase (ASNase) against asparagine synthetase (ASNS)-positive cell types requires ASNase glutaminase activity, whereas anticancer activity against ASNS-negative cell types does...
3.
Horvath T, Chan W, Pontikos M, Martin L, Du D, Tan L, et al.
Metabolites
. 2019 Jan;
9(1).
PMID: 30634463
l-asparaginase (ASNase) is a metabolism-targeted anti-neoplastic agent used to treat acute lymphoblastic leukemia (ALL). ASNase's anticancer activity results from the enzymatic depletion of asparagine (Asn) and glutamine (Gln), which are...
4.
Shirazi F, Pontikos M, Walsh T, Albert N, Lewis R, Kontoyiannis D
Antimicrob Agents Chemother
. 2013 Jul;
57(9):4360-8.
PMID: 23817366
The high mortality rate of mucormycosis with currently available monotherapy has created interest in studying novel strategies for antifungal agents. With the exception of amphotericin B (AMB), the triazoles (posaconazole...