John N Weinstein
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Explore the profile of John N Weinstein including associated specialties, affiliations and a list of published articles.
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196
Citations
30887
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Recent Articles
1.
Mahmud I, Chan W, Yannell K, Simmermaker C, Van de Bittner G, Wu L, et al.
bioRxiv
. 2025 Mar;
PMID: 40027784
Poor therapeutic index is a principal cause of drug attrition during development. A case in point is L-asparaginase (ASNase), an enzyme-drug approved for treatment of pediatric acute lymphoblastic leukemia (ALL)...
2.
Mahmud I, Wei B, Veillon L, Tan L, Martinez S, Tran B, et al.
Nat Commun
. 2025 Feb;
16(1):1347.
PMID: 39905052
Ion suppression is a major problem in mass spectrometry (MS)-based metabolomics; it can dramatically decrease measurement accuracy, precision, and sensitivity. Here we report a method, the IROA TruQuant Workflow, that...
3.
Lee O, Karyadi D, Hartley S, Zhou W, Zhou W, Machiela M, et al.
Eur Thyroid J
. 2025 Jan;
14(1).
PMID: 39773491
Deletion of the long q arm of chromosome 22 (22qDEL) is the most frequently identified recurrent somatic copy number alteration observed in papillary thyroid carcinoma (PTC). Since its role in...
4.
Guo S, Liu X, Cheng X, Jiang Y, Ji S, Liang Q, et al.
Genome Res
. 2024 Nov;
35(1):147-161.
PMID: 39586714
Bulk deconvolution with single-cell/nucleus RNA-seq data is critical for understanding heterogeneity in complex biological samples, yet the technological discrepancy across sequencing platforms limits deconvolution accuracy. To address this, we utilize...
5.
Xiong Y, Tan L, Chan W, Yin E, Donepudi S, Ding J, et al.
bioRxiv
. 2024 Oct;
PMID: 39386681
Rapid and comprehensive analysis of complex proteomes across large sample sets is vital for unlocking the potential of systems biology. We present UFP-MS, an ultra-fast mass spectrometry (MS) proteomics method...
6.
Sundaram L, Kumar A, Zatzman M, Salcedo A, Ravindra N, Shams S, et al.
Science
. 2024 Sep;
385(6713):eadk9217.
PMID: 39236169
To identify cancer-associated gene regulatory changes, we generated single-cell chromatin accessibility landscapes across eight tumor types as part of The Cancer Genome Atlas. Tumor chromatin accessibility is strongly influenced by...
7.
Mahmud I, Wei B, Veillon L, Tan L, Martinez S, Tran B, et al.
Res Sq
. 2024 Feb;
PMID: 38352620
Ion suppression is a major problem in mass spectrometry (MS)-based metabolomics; it can dramatically decrease measurement accuracy, precision, and signal-to-noise sensitivity. Here we report a new method, the IROA TruQuant...
8.
Liu Y, Lawson B, Huang X, Broom B, Weinstein J
Cancers (Basel)
. 2024 Feb;
16(3).
PMID: 38339431
The journal and authors wish to retract the article entitled 'Prediction of Ovarian Cancer Response to Therapy Based on Deep Learning Analysis of Histopathology Images' cited above [...].
9.
Zhang N, Casasent T, Casasent A, Kumar S, Wakefield C, Broom B, et al.
bioRxiv
. 2024 Jan;
PMID: 38260566
Background: Principal component analysis (PCA), a standard approach to analysis and visualization of large datasets, is commonly used in biomedical research for detecting similarities and differences among groups of samples....
10.
Guo S, Liu X, Cheng X, Jiang Y, Ji S, Liang Q, et al.
bioRxiv
. 2023 Oct;
PMID: 37873318
Bulk deconvolution with single-cell/nucleus RNA-seq data is critical for understanding heterogeneity in complex biological samples, yet the technological discrepancy across sequencing platforms limits deconvolution accuracy. To address this, we introduce...