Michael A Pack
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Explore the profile of Michael A Pack including associated specialties, affiliations and a list of published articles.
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13
Citations
480
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Recent Articles
1.
Liu Y, Murazzi I, Fuller A, Pan H, Irizarry-Negron V, DeVine A, et al.
Cancer Res
. 2024 Feb;
84(7):977-993.
PMID: 38335278
Significance: Collagen type VI modified by hypoxia-induced PLOD2 is secreted by sarcoma cells and binds to integrin β1 on endothelial cells to induce barrier dysfunction, which promotes sarcoma vascular dissemination...
2.
Bedell V, Meng Q, Pack M, Eckenhoff R
Sci Rep
. 2020 Sep;
10(1):15789.
PMID: 32978423
The field of neuropharmacology has not yet achieved a full understanding of how the brain transitions between states of consciousness and drug-induced unconsciousness, or anesthesia. Many small molecules are used...
3.
Ye S, Liu Y, Fuller A, Katti R, Ciotti G, Chor S, et al.
Mol Cancer Res
. 2020 Jan;
18(4):560-573.
PMID: 31988250
High-grade sarcomas are metastatic and pose a serious threat to patient survival. Undifferentiated pleomorphic sarcoma (UPS) is a particularly dangerous and relatively common sarcoma subtype diagnosed in adults. UPS contains...
4.
Gilbert M, Schultz-Rogers L, Rajagopalan R, Grochowski C, Wilkins B, Biswas S, et al.
Hum Mutat
. 2020 Jan;
41(5):973-982.
PMID: 31944481
Gastrointestinal motility disorders include a spectrum of mild to severe clinical phenotypes that are caused by smooth muscle dysfunction. We investigated the genetic etiology of severe esophageal, gastric, and colonic...
5.
Ko Y, Yi H, Qiu C, Huang S, Park J, Ledo N, et al.
Am J Hum Genet
. 2017 Jun;
100(6):940-953.
PMID: 28575649
Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to 10% of the US population. Genome-wide association studies (GWASs) have identified sequence variants, localized to non-coding genomic regions,...
6.
Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, et al.
J Clin Invest
. 2010 Jul;
120(8):2795-804.
PMID: 20592472
Cerebral cavernous malformation is a common human vascular disease that arises due to loss-of-function mutations in genes encoding three intracellular adaptor proteins, cerebral cavernous malformations 1 protein (CCM1), CCM2, and...
7.
Graziotto J, Inglehearn C, Pack M, Pierce E
Invest Ophthalmol Vis Sci
. 2008 Jun;
49(9):3830-8.
PMID: 18552388
Purpose: Pre-mRNA processing factor 3 (PRPF3) is a spliceosomal component essential for pre-mRNA processing. Mutations in PRPF3 have been implicated in retinitis pigmentosa (RP) 18 through an unknown mechanism. The...
8.
Lucitt M, Price T, Pizarro A, Wu W, Yocum A, Seiler C, et al.
Mol Cell Proteomics
. 2008 Jan;
7(5):981-94.
PMID: 18212345
The model organism zebrafish (Danio rerio) is particularly amenable to studies deciphering regulatory genetic networks in vertebrate development, biology, and pharmacology. Unraveling the functional dynamics of such networks requires precise...
9.
Pini B, Grosser T, Lawson J, Price T, Pack M, FitzGerald G
Arterioscler Thromb Vasc Biol
. 2004 Dec;
25(2):315-20.
PMID: 15576635
Objective: Prostaglandin E synthases (PGESs) are being explored as antiinflammatory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE(2) formation, and deletion of microsomal...
10.
Lin J, Biankin A, Horb M, Ghosh B, Prasad N, Yee N, et al.
Dev Biol
. 2004 Dec;
274(2):491-503.
PMID: 15570689
Mammalian studies have implicated important roles for the basic helix-loop-helix transcription factor Ptf1a-p48 in the development of both exocrine and endocrine pancreas. We have cloned the Ptf1a-p48 ortholog in Danio...