Sarcoma Cells Secrete Hypoxia-Modified Collagen VI to Weaken the Lung Endothelial Barrier and Promote Metastasis

Overview

Journal Cancer Res

Specialty Oncology

Date 2024 Feb 9

PMID 38335278

Authors

Ying Liu

Ileana Murazzi

Ashley M Fuller

Hehai Pan

Valerie M Irizarry-Negron

Ann DeVine

Rohan Katti

Nicolas Skuli

Gabrielle E Ciotti

Koreana Pak

Michael A Pack

M Celeste Simon

Kristy Weber

Kumarasen Cooper

T S Karin Eisinger-Mathason

Affiliations

Soon will be listed here.

Abstract

Significance: Collagen type VI modified by hypoxia-induced PLOD2 is secreted by sarcoma cells and binds to integrin β1 on endothelial cells to induce barrier dysfunction, which promotes sarcoma vascular dissemination and metastasis.

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