Michael A Mohutsky
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Explore the profile of Michael A Mohutsky including associated specialties, affiliations and a list of published articles.
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21
Citations
136
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Recent Articles
11.
Moulton R, Ruterbories K, Bedwell D, Mohutsky M
Drug Metab Dispos
. 2015 Mar;
43(5):756-61.
PMID: 25755052
To characterize the hydrolysis of the peptide prodrug pomaglumetad methionil (LY2140023; (1R,4S,5S,6S)-4-(L-methionylamino)-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide), to the active drug LY404039 [(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide], a series of in vitro studies were performed...
12.
Zamek-Gliszczynski M, Mohutsky M, Rehmel J, Ke A
Drug Metab Dispos
. 2014 Mar;
42(6):1008-15.
PMID: 24658455
The glycogen synthase kinase-3 inhibitor LY2090314 specifically impaired CYP2B6 activity during in vitro evaluation of cytochrome P450 (P450) enzyme induction in human hepatocytes. CYP2B6 catalytic activity was significantly decreased following...
13.
Mao J, Mohutsky M, Harrelson J, Wrighton S, Hall S
Drug Metab Dispos
. 2012 Jan;
40(4):706-16.
PMID: 22228749
Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and time-dependent inhibition. The goal...
14.
Danielson M, Desai P, Mohutsky M, Wrighton S, Lill M
Eur J Med Chem
. 2011 Jun;
46(9):3953-63.
PMID: 21703735
Cytochrome P450 enzymes are responsible for metabolizing many endogenous and xenobiotic molecules encountered by the human body. It has been estimated that 75% of all drugs are metabolized by cytochrome...
15.
Mao J, Mohutsky M, Harrelson J, Wrighton S, Hall S
Drug Metab Dispos
. 2011 Jan;
39(4):591-602.
PMID: 21212240
Cryopreserved human hepatocytes suspended in human plasma (HHSHP) represent an integrated metabolic environment for predicting drug-drug interactions (DDIs). In this study, 13 CYP3A reversible and/or time-dependent inhibitors (TDIs) were incubated...
16.
Mohutsky M, Romeike A, Meador V, Lee W, Fowler J, Francke-Carroll S
Toxicol Pathol
. 2010 Jul;
38(5):799-809.
PMID: 20616377
Hepatic drug metabolizing enzyme (DME) induction complicates the development of new drugs owing to altered efficacy of concomitant treatments, reduction in exposure resulting from autoinduction, and potential generation of toxic...
17.
Dennison J, Mohutsky M, Barbuch R, Wrighton S, Hall S
J Pharmacol Exp Ther
. 2008 Jul;
327(1):248-57.
PMID: 18650247
Vincristine is metabolized to one primary metabolite, M1, by cDNA-expressed CYP3A4 and CYP3A5 and by CYP3A enzymes in human liver microsomes. For both systems, CYP3A5 is predicted to mediate approximately...
18.
Hashizume T, Xu Y, Mohutsky M, Alberts J, Hadden C, Kalhorn T, et al.
Biochem Pharmacol
. 2008 Jan;
75(5):1240-50.
PMID: 18177842
The biological effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) are terminated primarily by P450-dependent hydroxylation reactions. However, the hormone is also conjugated in the liver and a metabolite, presumably a glucuronide, undergoes...
19.
Mohutsky M, Chien J, Ring B, Wrighton S
Pharm Res
. 2006 Mar;
23(4):654-62.
PMID: 16550474
Purpose: The utility of in vitro metabolism to accurately predict the clearance of hepatically metabolized drugs was evaluated. Three major goals were: (1) to optimize substrate concentration for the accurate...
20.
Mohutsky M, Anderson G, Miller J, Elmer G
Am J Ther
. 2006 Jan;
13(1):24-31.
PMID: 16428919
Ginkgo biloba extract is one of the most widely used herbal products in the United States. However, bleeding episodes in patients taking Ginkgo biloba and warfarin have been documented. Therefore,...