Ansgar Wegener
Overview
Explore the profile of Ansgar Wegener including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
336
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0
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Recent Articles
1.
Paiva A, Lemos A, Busse P, Martins M, Silva D, Freitas M, et al.
Biosensors (Basel)
. 2023 Oct;
13(10).
PMID: 37887106
Modern drug discovery relies on combinatorial screening campaigns to find drug molecules targeting specific disease-associated proteins. The success of such campaigns often relies on functional and structural information of the...
2.
Gradler U, Schwarz D, Wegener A, Eichhorn T, Bandeiras T, Freitas M, et al.
J Biol Chem
. 2023 Oct;
299(11):105328.
PMID: 37806493
The receptor tyrosine kinase MET is activated by hepatocyte growth factor binding, followed by phosphorylation of the intracellular kinase domain (KD) mainly within the activation loop (A-loop) on Y1234 and...
3.
Buchstaller H, Sala-Hojman A, Leiendecker M, Albers J, Anlauf U, Berges N, et al.
J Med Chem
. 2023 Jul;
66(13):8666-8686.
PMID: 37403966
Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors induced in diverse pathophysiological settings. Inhibition of HIF-2α has become a strategy for cancer treatment since the discovery that small molecules, upon binding...
4.
Heinrich T, Sala-Hojman A, Ferretti R, Petersson C, Minguzzi S, Gondela A, et al.
J Med Chem
. 2021 Aug;
64(16):11904-11933.
PMID: 34382802
Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate...
5.
Buchstaller H, Anlauf U, Dorsch D, Kogler S, Kuhn D, Lehmann M, et al.
J Med Chem
. 2021 Jul;
64(14):10371-10392.
PMID: 34255518
Constitutive activation of the canonical Wnt signaling pathway, in most cases driven by inactivation of the tumor suppressor APC, is a hallmark of colorectal cancer. Tankyrases are druggable key regulators...
6.
Schindler C, Baumann H, Blum A, Bose D, Buchstaller H, Burgdorf L, et al.
J Chem Inf Model
. 2020 Aug;
60(11):5457-5474.
PMID: 32813975
Accurate ranking of compounds with regards to their binding affinity to a protein using computational methods is of great interest to pharmaceutical research. Physics-based free energy calculations are regarded as...
7.
Heinrich T, Seenisamy J, Becker F, Blume B, Bomke J, Dietz M, et al.
J Med Chem
. 2019 Nov;
62(24):11119-11134.
PMID: 31725285
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound suffered from enterohepatic circulation, preventing further development. Nevertheless,...
8.
Broer A, Gauthier-Coles G, Rahimi F, van Geldermalsen M, Dorsch D, Wegener A, et al.
J Biol Chem
. 2019 Jan;
294(11):4012-4026.
PMID: 30635397
The neutral amino acid transporter solute carrier family 1 member 5 (SLC1A5 or ASCT2) is overexpressed in many cancers. To identify its roles in tumors, we employed 143B osteosarcoma cells...
9.
Schlecht R, Scholz S, Dahmen H, Wegener A, Sirrenberg C, Musil D, et al.
PLoS One
. 2013 Nov;
8(11):e78443.
PMID: 24265689
The molecular chaperones of the Hsp70 family have been recognized as targets for anti-cancer therapy. Since several paralogs of Hsp70 proteins exist in cytosol, endoplasmic reticulum and mitochondria, we investigated...
10.
Gradler U, Schwarz D, Dresing V, Musil D, Bomke J, Frech M, et al.
J Mol Biol
. 2012 Nov;
425(2):309-33.
PMID: 23154170
Syk is an essential non-receptor tyrosine kinase in intracellular immunological signaling, and the control of Syk kinase function is considered as a valuable target for pharmacological intervention in autoimmune or...