Mette A Peters
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Explore the profile of Mette A Peters including associated specialties, affiliations and a list of published articles.
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30
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2812
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Recent Articles
1.
Wen C, Margolis M, Dai R, Zhang P, Przytycki P, Vo D, et al.
Science
. 2024 May;
384(6698):eadh0829.
PMID: 38781368
Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain. However, prioritizing risk genes and mechanisms is...
2.
Garrison M, Jang Y, Bae T, Cherskov A, Emery S, Fasching L, et al.
Sci Data
. 2023 Nov;
10(1):813.
PMID: 37985666
Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single...
3.
Wen C, Margolis M, Dai R, Zhang P, Przytycki P, Vo D, et al.
medRxiv
. 2023 Mar;
PMID: 36945630
Genomic regulatory elements active in the developing human brain are notably enriched in genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD), schizophrenia, and bipolar disorder. However, prioritizing the...
4.
Girdhar K, Hoffman G, Bendl J, Rahman S, Dong P, Liao W, et al.
Nat Neurosci
. 2022 Mar;
25(4):474-483.
PMID: 35332326
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains largely unexplored in the human brain. In...
5.
Hoffman G, Ma Y, Montgomery K, Bendl J, Jaiswal M, Kozlenkov A, et al.
Biol Psychiatry
. 2021 Jun;
91(1):92-101.
PMID: 34154796
Background: While schizophrenia differs between males and females in the age of onset, symptomatology, and disease course, the molecular mechanisms underlying these differences remain uncharacterized. Methods: To address questions about...
6.
Wang Y, Bae T, Thorpe J, Sherman M, Jones A, Cho S, et al.
Genome Biol
. 2021 Mar;
22(1):92.
PMID: 33781308
Background: Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. However, detecting...
7.
Greenwood A, Montgomery K, Kauer N, Woo K, Leanza Z, Poehlman W, et al.
Curr Protoc Hum Genet
. 2020 Oct;
108(1):e105.
PMID: 33085189
The AD Knowledge Portal (adknowledgeportal.org) is a public data repository that shares data and other resources generated by multiple collaborative research programs focused on aging, dementia, and Alzheimer's disease (AD)....
8.
Sieberts S, Perumal T, Carrasquillo M, Allen M, Reddy J, Hoffman G, et al.
Sci Data
. 2020 Oct;
7(1):340.
PMID: 33046718
The availability of high-quality RNA-sequencing and genotyping data of post-mortem brain collections from consortia such as CommonMind Consortium (CMC) and the Accelerating Medicines Partnership for Alzheimer's Disease (AMP-AD) Consortium enable...
9.
Han L, Zhao X, Benton M, Perumal T, Collins R, Hoffman G, et al.
Nat Commun
. 2020 Jun;
11(1):2990.
PMID: 32533064
Structural variants (SVs) contribute to many disorders, yet, functionally annotating them remains a major challenge. Here, we integrate SVs with RNA-sequencing from human post-mortem brains to quantify their dosage and...
10.
Hoffman G, Bendl J, Voloudakis G, Montgomery K, Sloofman L, Wang Y, et al.
Sci Data
. 2019 Sep;
6(1):180.
PMID: 31551426
Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is known...