Melkam A Kebede
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Explore the profile of Melkam A Kebede including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
314
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Recent Articles
1.
Hao H, Yuan Y, Ito A, Eberand B, Tjondro H, Cielesh M, et al.
Nat Chem Biol
. 2025 Jan;
PMID: 39775168
O-Fucosylation plays crucial roles in various essential biological events. Alongside the well-established O-fucosylation of epidermal growth factor-like repeats by protein O-fucosyltransferase 1 (POFUT1) and thrombospondin type 1 repeats by POFUT2,...
2.
Yau B, An Y, Germanos M, Schwarzkopf P, van der Kraan A, Larance M, et al.
Am J Physiol Endocrinol Metab
. 2024 Dec;
328(3):E457-E469.
PMID: 39716868
Vacuolar protein sorting-associated protein 41 (VPS41) has been established as a requirement for normal insulin secretory function in pancreatic β cells. Genetic deletion of in mouse pancreatic β cells results...
3.
Norris N, Yau B, Famularo C, Webster H, Loudovaris T, Thomas H, et al.
Diabetes
. 2024 Sep;
73(12):2045-2054.
PMID: 39320956
Article Highlights:
4.
Thillainadesan S, Lambert A, Cooke K, Stockli J, Yau B, Masson S, et al.
Int J Obes (Lond)
. 2024 Jul;
48(8):1170-1179.
PMID: 38961153
Background: Weight loss can improve the metabolic complications of obesity. However, it is unclear whether insulin resistance persists despite weight loss and whether any protective benefits are preserved following weight...
5.
Diaz-Vegas A, Cooke K, Cutler H, Yau B, Masson S, Harney D, et al.
Mol Metab
. 2024 Jul;
86:101983.
PMID: 38960128
Objective: To determine the role of miPEP in insulin resistance. Methods: To experimentally test this observation, we generated adipocyte-specific miPEP knockout mice to interrogate its role in the aetiology of...
6.
Yau B, Madsen S, Nelson M, Cooke K, Fritzen A, Thorius I, et al.
Am J Physiol Endocrinol Metab
. 2024 Apr;
326(5):E663-E672.
PMID: 38568150
Despite the fact that genes and the environment are known to play a central role in islet function, our knowledge of how these parameters interact to modulate insulin secretory function...
7.
Yau B, Naghiloo S, Diaz-Vegas A, Carr A, van Gerwen J, Needham E, et al.
iScience
. 2024 Jan;
27(1):108707.
PMID: 38188515
[This corrects the article DOI: 10.1016/j.isci.2021.103099.].
8.
Keller M, Hudkins K, Shalev A, Bhatnagar S, Kebede M, Merrins M, et al.
iScience
. 2023 Jun;
26(7):107036.
PMID: 37360692
Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been...
9.
Thai L, OReilly L, Reibe-Pal S, Sue N, Holliday H, Small L, et al.
iScience
. 2023 Apr;
26(4):106477.
PMID: 37091234
We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage function, focusing on more physiological conditions than the commonly used extremes of M1 (inflammation) versus M2 (tissue remodeling)...
10.
Brandon A, Small L, Nguyen T, Suryana E, Gong H, Yassmin C, et al.
Elife
. 2022 Nov;
11.
PMID: 36394259
Obesity is generally associated with insulin resistance in liver and muscle and increased risk of developing type 2 diabetes, however there is a population of obese people that remain insulin...