Melissa R Junttila
Overview
Explore the profile of Melissa R Junttila including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
4930
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Recent Articles
1.
Chen C, Khanna V, Kummar S, Abdul-Karim R, Sommerhalder D, Tolcher A, et al.
Cancer Res Commun
. 2024 Aug;
4(9):2415-2426.
PMID: 39177285
Purpose: In preclinical models, glucocorticoid receptor (GR) signaling drives resistance to taxane chemotherapy in multiple solid tumors via upregulation of antiapoptotic pathways. ORIC-101 is a potent and selective GR antagonist...
2.
Ray A, Du T, Wan X, Song Y, Pillai S, Musa M, et al.
Blood Cancer J
. 2024 Apr;
14(1):58.
PMID: 38594241
No abstract available.
3.
Abida W, Hahn A, Shore N, Agarwal N, Sieber P, Smith M, et al.
Clin Cancer Res
. 2024 Jan;
30(6):1111-1120.
PMID: 38226958
Purpose: Increased glucocorticoid receptor (GR) signaling is a proposed compensatory mechanism of resistance to androgen receptor (AR) inhibition in metastatic castration-resistant prostate cancer (mCRPC). ORIC-101 is a potent and selective...
4.
Dorso M, Patel P, Pankov A, Boyer J, Soni R, Del Priore I, et al.
Cancer Res Commun
. 2023 Sep;
3(9):1788-1799.
PMID: 37691854
Significance: NSCLC is the leading cause of cancer deaths worldwide. There is a need to identify novel druggable dependencies. We identify a subset of NSCLCs dependent on FOXA1-GR and sensitive...
5.
Ferl G, Barck K, Patil J, Jemaa S, Malamut E, Lima A, et al.
iScience
. 2022 Dec;
25(12):105712.
PMID: 36582483
Here, we have developed an automated image processing algorithm for segmenting lungs and individual lung tumors in micro-computed tomography (micro-CT) scans of mouse models of non-small cell lung cancer and...
6.
Pribluda A, Daemen A, Lima A, Wang X, Hafner M, Poon C, et al.
Elife
. 2022 Aug;
11.
PMID: 35983994
Lung development, integrity and repair rely on precise Wnt signaling, which is corrupted in diverse diseases, including cancer. Here, we discover that EHMT2 methyltransferase regulates Wnt signaling in the lung...
7.
Venkatanarayan A, Liang J, Yen I, Shanahan F, Haley B, Phu L, et al.
Cell Rep
. 2022 Feb;
38(6):110351.
PMID: 35139374
KRAS, which is mutated in ∼30% of all cancers, activates the RAF-MEK-ERK signaling cascade. CRAF is required for growth of KRAS mutant lung tumors, but the requirement for CRAF kinase...
8.
Munne P, Martikainen L, Raty I, Bertula K, Nonappa , Ruuska J, et al.
Nat Commun
. 2021 Nov;
12(1):6967.
PMID: 34845227
Breast cancer is now globally the most frequent cancer and leading cause of women's death. Two thirds of breast cancers express the luminal estrogen receptor-positive (ERα + ) phenotype that...
9.
Honkala A, V Malhotra S, Kummar S, Junttila M
Nat Rev Drug Discov
. 2021 Oct;
21(2):99-114.
PMID: 34702990
Recent progress in understanding the molecular basis of cellular processes, identification of promising therapeutic targets and evolution of the regulatory landscape makes this an exciting and unprecedented time to be...
10.
Daemen A, Cooper J, Myrta S, Wongchenko M, Lin E, Long J, et al.
Clin Cancer Res
. 2020 Oct;
27(4):1162-1173.
PMID: 33023953
Purpose: Lung adenocarcinomas comprise the largest fraction of non-small cell lung cancer, which is the leading cause of cancer-related deaths. Seventy-five percent of adenocarcinomas lack targeted therapies because of scarcity...