Melissa Loren
Overview
Explore the profile of Melissa Loren including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
227
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0
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Recent Articles
1.
Dings R, Kumar N, Miller M, Loren M, Rangwala H, Hoye T, et al.
J Pharmacol Exp Ther
. 2012 Dec;
344(3):589-99.
PMID: 23232447
Galectin-1 (gal-1), which binds β-galactoside groups on various cell surface receptors, is crucial to cell adhesion and migration, and is found to be elevated in several cancers. Previously, we reported...
2.
Dings R, Van Laar E, Loren M, Webber J, Zhang Y, Waters S, et al.
Bioconjug Chem
. 2009 Dec;
21(1):20-7.
PMID: 20020769
Targeted delivery of therapeutic drugs promises to become the norm to treat cancer. Here, we conjugated the cytotoxic agent 6-hydroxypropylacylfulvene (HPAF) to anginex, a peptide that targets galectin-1, which is...
3.
Visaria R, Bischof J, Loren M, Williams B, Ebbini E, Paciotti G, et al.
Int J Hyperthermia
. 2007 Oct;
23(6):501-11.
PMID: 17952764
Purpose: The current work describes the synergistic enhancement of hyperthermic cancer therapy by selective thermal sensitization and induction of vascular injury at the tumor site. The specificity of this response...
4.
Choi E, Terai K, Ji I, Kook Y, Park K, Oh E, et al.
Neoplasia
. 2007 Sep;
9(8):634-42.
PMID: 17786182
We found that beta-lapachone (beta-lap), a novel bioreductive drug, caused rapid apoptosis and clonogenic cell death in A549 human lung epithelial cancer cells in vitro in a dose-dependent manner. The...
5.
Dings R, Loren M, Heun H, McNiel E, Griffioen A, Mayo K, et al.
Clin Cancer Res
. 2007 Jun;
13(11):3395-402.
PMID: 17545548
Purpose: To test whether a direct antiangiogenic peptide (anginex) and a vascular endothelial growth factor antibody (bevacizumab, Avastin) can transiently normalize vasculature within tumors to improve oxygen delivery, alleviate hypoxia,...