Thomas R Hoye
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Explore the profile of Thomas R Hoye including associated specialties, affiliations and a list of published articles.
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161
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1870
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Recent Articles
1.
Sneddon D, Kevorkian P, Hoye T
Chem Sci
. 2025 Jan;
16(6):2898-2906.
PMID: 39822903
The hexadehydro-Diels-Alder (HDDA) reaction is a cycloisomerization between a conjugated diyne and a tethered diynophile that generates -benzyne derivatives. Considerable fundamental understanding of aryne reactivity has resulted from this body...
2.
Kaicharla T, Jin M, Hoye T
J Am Chem Soc
. 2024 Dec;
146(50):34510-34516.
PMID: 39641921
We show that 2-diynylpyridine and a Bpin-terminated monoyne or diyne will cross-react to form benzyne intermediates. These reactive intermediates are captured by various in situ trapping agents to give products...
3.
Guzman A, Mann A, Hoye T
J Am Chem Soc
. 2024 Oct;
146(42):28642-28647.
PMID: 39383055
Carbenes and carbenoids are commonly employed for the synthesis of cyclopropane-containing compounds. Here we report the metal-free, intramolecular cyclopropanation of tethered alkenes by free carbenes derived from alkynes to construct...
4.
Wang R, Xu Q, Hoye T
Org Lett
. 2024 Sep;
26(37):7805-7808.
PMID: 39254483
A pyridine containing a 2-alkynyl substituent armed with a carbene reporter group [R = C(Me)OAc] is shown to engage electrophilic allenes to generate intermediate free carbenes. Depending on the electron...
5.
Wheeler A, Ahn S, Kraemer N, Hoye T
J Org Chem
. 2024 Sep;
89(18):13485-13490.
PMID: 39238420
The relative reactivity of a systematic series of simple aliphatic acetate esters has been measured. Exposure of pairs of esters of increasing remote steric hindrance (by altering the degree of...
6.
Lee S, Hoye T
Org Lett
. 2024 Jul;
26(27):5713-5718.
PMID: 38949145
1,3-Dipolar cycloadditions of azoxy species are rare. HOBT exists as a pair of tautomers, one of which contains an azoxy subunit. We show that heavily substituted, thermally generated benzynes react...
7.
Xu Q, Hoye T
Nat Chem
. 2024 Jun;
16(7):1083-1092.
PMID: 38918579
Carbenes (RRC:) like radicals, arynes and nitrenes constitute an important family of neutral, high-energy, reactive intermediates-fleeting chemical entities that undergo rapid reactions. An alkyne (RC≡CR) is a fundamental functional group...
8.
Jin M, Hoye T
Macromolecules
. 2024 May;
56(3):1122-1129.
PMID: 38817685
The purpose of this study was to learn if a convenient H NMR method could be developed to serve as a tool for estimating the propensity of a given lactone...
9.
Chinta B, Sneddon D, Hoye T
Chem Sci
. 2024 May;
15(21):8181-8189.
PMID: 38817592
Intramolecular net [2 + 2] cycloadditions between benzyne intermediates and an electron-deficient alkene to give benzocyclobutene intermediates are relatively rare. Benzynes are electrophilic and generally engage nucleophiles or electron-rich π-systems....
10.
Guzman A, Kevorkian P, Hoye T
Org Lett
. 2024 Apr;
26(18):3834-3839.
PMID: 38686996
2:1 adducts arise from the reaction of 2,5-diaryl-1,3,4-oxadiazoles and benzynes generated from the hexadehydro-Diels-Alder (HDDA) reaction. Density functional theory computations support a mechanistic manifold that includes a concerted SAr process....