Melania Pintilie
Overview
Explore the profile of Melania Pintilie including associated specialties, affiliations and a list of published articles.
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Articles
197
Citations
7167
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Recent Articles
1.
Lukovic J, Pintilie M, Han K, Fyles A, Bruce J, Quevedo R, et al.
Clin Cancer Res
. 2024 Jan;
30(6):1200-1207.
PMID: 38180733
Purpose: To develop an immune-based gene expression risk score to identify patients with cervical cancer at increased risk of distant metastases (DM). Experimental Design: Tumor biopsies were obtained from 81...
2.
Marastoni S, Madariaga A, Pesic A, Nair S, Li Z, Shalev Z, et al.
Cancer Res Commun
. 2023 Mar;
2(5):293-306.
PMID: 36875717
Significance: The combination of the antifungal drug itraconazole with antimalarial drug hydroxychloroquine leads to a cytotoxic lysosomal dysfunction, supporting the rational for further research on lysosomal targeting in ovarian cancer.
3.
Weiss J, Pham N, Pintilie M, Li M, Liu G, Shepherd F, et al.
Cancer Inform
. 2022 Nov;
21:11769351221136056.
PMID: 36439025
Patient-derived tumor xenograft (PDX) models were used to evaluate the effectiveness of preclinical anticancer agents. A design using 1 mouse per patient per drug (1 × 1 × 1) was...
4.
Mirhadi S, Zhang W, Pham N, Karimzadeh F, Pintilie M, Tong J, et al.
Mol Cancer Res
. 2022 Oct;
21(1):36-50.
PMID: 36214668
Implications: FeS cluster-associated proteins including ACO2, mNT (encoded by CISD1), and IRP1 (encoded by ACO1) are part of an "ACO2-Iron Axis" that regulates iron homeostasis and is a determinant of...
5.
Han K, Fyles A, Shek T, Croke J, Dhani N, DSouza D, et al.
Clin Cancer Res
. 2022 Aug;
28(24):5263-5271.
PMID: 36037303
Purpose: Tumor hypoxia is associated with poor response to radiation (RT). We previously discovered a novel mechanism of metformin: enhancing tumor RT response by decreasing tumor hypoxia. We hypothesized that...
6.
Siddiqui I, Bilkey J, McKee T, Serra S, Pintilie M, Do T, et al.
Front Oncol
. 2022 Aug;
12:926497.
PMID: 35978831
Background: Tumor hypoxia is theorized to contribute to the aggressive biology of pancreatic ductal adenocarcinoma (PDAC). We previously reported that hypoxia correlated with rapid tumor growth and metastasis in patient-derived...
7.
Han K, Leung E, Barbera L, Barnes E, Croke J, Di Grappa M, et al.
JCO Precis Oncol
. 2022 Feb;
2:1-8.
PMID: 35135145
Purpose: To determine whether plasma human papillomavirus (HPV) DNA predates clinical recurrence and compare its accuracy with 3-month fluorodeoxyglucose positron emission tomography (FDG-PET) in locally advanced cervical cancer. Methods: This...
8.
Ramotar M, Chua M, Truong H, Hosni A, Pintilie M, Davicioni E, et al.
Urol Oncol
. 2021 Sep;
40(1):5.e1-5.e13.
PMID: 34538726
Purpose/objective: Risk-stratification for post-prostatectomy radiotherapy (PORT) using conventional clinicopathologic indexes leads to substantial over- and under-treatment. Better patient selection could spare unnecessary toxicities and improve outcomes. We investigated the prognostic...
9.
Pham N, Radulovich N, Ibrahimov E, Martins-Filho S, Li Q, Pintilie M, et al.
Sci Rep
. 2021 May;
11(1):10619.
PMID: 34011980
Patient-derived xenograft (PDX) and their xenograft-derived organoid (XDO) models that recapitulate the genotypic and phenotypic landscape of patient cancers could help to advance research and lead to improved clinical management. ...
10.
Iafolla M, Yang C, Chandran V, Pintilie M, Li Q, Bedard P, et al.
JNCI Cancer Spectr
. 2021 Feb;
5(1).
PMID: 33554038
Background: Human leukocyte antigen class 1 (HLA-1)-dependent immune activity is linked to autoimmune diseases. HLA-1-dependent CD8 T cells are required for immune checkpoint blockade antitumor activity. It is unknown if...