Meike Wiese
Overview
Explore the profile of Meike Wiese including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
173
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0
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Recent Articles
1.
Sun Y, Wiese M, Hmadi R, Karayol R, Seyfferth J, Martinez Greene J, et al.
Nature
. 2023 Nov;
624(7990):173-181.
PMID: 38030723
In diploid organisms, biallelic gene expression enables the production of adequate levels of mRNA. This is essential for haploinsufficient genes, which require biallelic expression for optimal function to prevent the...
2.
Tsang T, Wiese M, Helmstadter M, Stehle T, Seyfferth J, Shvedunova M, et al.
Sci Adv
. 2023 Aug;
9(34):eadh5598.
PMID: 37624894
Members of the NSL histone acetyltransferase complex are involved in multiorgan developmental syndromes. While the NSL complex is known for its importance in early development, its role in fully differentiated...
3.
Novo C, Wong E, Hockings C, Poudel C, Sheekey E, Wiese M, et al.
Nat Commun
. 2022 Jun;
13(1):3525.
PMID: 35725842
Heterochromatin maintains genome integrity and function, and is organised into distinct nuclear domains. Some of these domains are proposed to form by phase separation through the accumulation of HP1ɑ. Mouse...
4.
Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice
Pessoa Rodrigues C, Chatterjee A, Wiese M, Stehle T, Szymanski W, Shvedunova M, et al.
Nat Commun
. 2021 Oct;
12(1):6212.
PMID: 34707105
Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators. However, the exact molecular...
5.
Wiese M, Bannister A
Mol Metab
. 2020 Mar;
38:100942.
PMID: 32217072
Background: Virtually all eukaryotic cells contain spatially distinct genomes, a single nuclear genome that harbours the vast majority of genes and much smaller genomes found in mitochondria present at thousands...
6.
Wiese M, Bannister A, Basu S, Boucher W, Wohlfahrt K, Christophorou M, et al.
Epigenetics Chromatin
. 2019 Apr;
12(1):21.
PMID: 30940194
Background: Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principal reader of the repressive histone...
7.
Gilan O, Lam E, Becher I, Lugo D, Cannizzaro E, Joberty G, et al.
Nat Struct Mol Biol
. 2016 Jun;
23(7):673-81.
PMID: 27294782
Targeted therapies against disruptor of telomeric silencing 1-like (DOT1L) and bromodomain-containing protein 4 (BRD4) are currently being evaluated in clinical trials. However, the mechanisms by which BRD4 and DOT1L regulate...
8.
Fisser M, Rommer A, Steinleitner K, Heller G, Herbst F, Wiese M, et al.
Mol Carcinog
. 2014 Dec;
54(12):1815-9.
PMID: 25491945
Even though a large proportion of patients with acute myeloid leukemia (AML) achieve a complete remission upon initial therapy, the majority of them eventually relapse with resistant disease. Overexpression of...