Cecilia Pessoa Rodrigues
Overview
Explore the profile of Cecilia Pessoa Rodrigues including associated specialties, affiliations and a list of published articles.
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15
Citations
470
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Recent Articles
1.
Gronke K, Nguyen M, Fuhrmann H, Santamaria de Souza N, Schumacher J, Pereira M, et al.
Sci Transl Med
. 2025 Feb;
17(784):eadj6294.
PMID: 39908347
Chronic autoimmune diseases often lead to long-term sequelae and require lifelong immunosuppression because of an incomplete understanding of the triggers and drivers in genetically predisposed patients. Gut bacteria that escape...
2.
Ludin A, Stirtz G, Tal A, Nirmal A, Besson N, Jones S, et al.
bioRxiv
. 2024 Sep;
PMID: 39345527
Immunotherapy leads to cancer eradication despite the tumor's immunosuppressive environment. Here, we used extended long-term in-vivo imaging and high-resolution spatial transcriptomics of endogenous melanoma in zebrafish, and multiplex imaging of...
3.
Pessoa Rodrigues C, Collins J, Yang S, Martinez C, Kim J, Lama C, et al.
Science
. 2024 Sep;
385(6714):eadn1629.
PMID: 39264994
Macrophages maintain hematopoietic stem cell (HSC) quality by assessing cell surface Calreticulin (Calr), an "eat-me" signal induced by reactive oxygen species (ROS). Using zebrafish genetics, we identified Beta-2-microglobulin (B2m) as...
4.
Sun Y, Wiese M, Hmadi R, Karayol R, Seyfferth J, Martinez Greene J, et al.
Nature
. 2023 Nov;
624(7990):173-181.
PMID: 38030723
In diploid organisms, biallelic gene expression enables the production of adequate levels of mRNA. This is essential for haploinsufficient genes, which require biallelic expression for optimal function to prevent the...
5.
Wattrus S, Smith M, Pessoa Rodrigues C, Hagedorn E, Kim J, Budnik B, et al.
Science
. 2022 Sep;
377(6613):1413-1419.
PMID: 36137040
Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis or transform to initiate cancer. Despite their importance, there are no described quality assurance mechanisms for newly...
6.
Rubin S, Baron C, Pessoa Rodrigues C, Duran M, Corbin A, Yang S, et al.
J Exp Med
. 2022 Aug;
219(9).
PMID: 35938989
The zebrafish has proven to be a valuable model organism for studying hematopoiesis, but relatively little is known about zebrafish immune cell development and functional diversity. Elucidating key aspects of...
7.
Pessoa Rodrigues C, Shvedunova M, Akhtar A
Trends Genet
. 2021 Nov;
PMID: 34756331
Hematopoiesis is the process by which both fetal and adult organisms derive the full repertoire of blood cells from a single multipotent progenitor cell type, the hematopoietic stem cells (HSCs)....
8.
Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice
Pessoa Rodrigues C, Chatterjee A, Wiese M, Stehle T, Szymanski W, Shvedunova M, et al.
Nat Commun
. 2021 Oct;
12(1):6212.
PMID: 34707105
Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators. However, the exact molecular...
9.
Pessoa Rodrigues C, Akhtar A
Sci Adv
. 2021 Aug;
7(32).
PMID: 34362741
Hematopoietic stem cells (HSCs) are able to reconstitute the bone marrow while retaining their self-renewal property. Individual HSCs demonstrate heterogeneity in their repopulating capacities. Here, we found that the levels...
10.
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate
Pessoa Rodrigues C, Herman J, Herquel B, Keller Valsecchi C, Stehle T, Grun D, et al.
Sci Adv
. 2020 Jul;
6(21):eaaz4815.
PMID: 32671208
Self-renewal and differentiation of hematopoietic stem cells (HSCs) are orchestrated by the combinatorial action of transcription factors and epigenetic regulators. Here, we have explored the mechanism by which histone H4...