Srinjan Basu
Overview
Explore the profile of Srinjan Basu including associated specialties, affiliations and a list of published articles.
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21
Citations
1046
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Recent Articles
1.
Pal D, Patel M, Boulet F, Sundarraj J, Grant O, Branco M, et al.
Nat Struct Mol Biol
. 2023 Jun;
30(7):935-947.
PMID: 37308596
Mammalian genomes harbor abundant transposable elements (TEs) and their remnants, with numerous epigenetic repression mechanisms enacted to silence TE transcription. However, TEs are upregulated during early development, neuronal lineage, and...
2.
Novo C, Wong E, Hockings C, Poudel C, Sheekey E, Wiese M, et al.
Nat Commun
. 2022 Jun;
13(1):3525.
PMID: 35725842
Heterochromatin maintains genome integrity and function, and is organised into distinct nuclear domains. Some of these domains are proposed to form by phase separation through the accumulation of HP1ɑ. Mouse...
3.
Sielaff H, Basu S, Zhao Z
Front Mol Biosci
. 2022 Jun;
9:929370.
PMID: 35669565
No abstract available.
4.
Steindel M, Orsine de Almeida I, Strawbridge S, Chernova V, Holcman D, Ponjavic A, et al.
Methods Mol Biol
. 2022 May;
2476:209-247.
PMID: 35635707
Single-molecule localization microscopy (SMLM) allows the super-resolved imaging of proteins within mammalian nuclei at spatial resolutions comparable to that of a nucleosome itself (~20 nm). The technique is therefore well...
5.
Wurmser A, Basu S
Front Mol Biosci
. 2022 May;
9:867303.
PMID: 35517868
-regulatory elements such as enhancers can be located even a million base pairs away from their cognate promoter and yet modulate gene transcription. Indeed, the 3D organisation of chromatin enables...
6.
Morf J, Basu S, Amaral P
Front Genet
. 2020 Nov;
11:589413.
PMID: 33193726
RNA, the transcriptional output of genomes, not only templates protein synthesis or directly engages in catalytic functions, but can feed back to the genome and serve as regulatory input for...
7.
Wiese M, Bannister A, Basu S, Boucher W, Wohlfahrt K, Christophorou M, et al.
Epigenetics Chromatin
. 2019 Apr;
12(1):21.
PMID: 30940194
Background: Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principal reader of the repressive histone...
8.
Basu S, Needham L, Lando D, Taylor E, Wohlfahrt K, Shah D, et al.
Nat Commun
. 2018 Jun;
9(1):2520.
PMID: 29955052
A major challenge in single-molecule imaging is tracking the dynamics of proteins or complexes for long periods of time in the dense environments found in living cells. Here, we introduce...
9.
Lando D, Basu S, Stevens T, Riddell A, Wohlfahrt K, Cao Y, et al.
Nat Protoc
. 2018 Apr;
13(5):1034-1061.
PMID: 29674753
Fluorescence imaging and chromosome conformation capture assays such as Hi-C are key tools for studying genome organization. However, traditionally, they have been carried out independently, making integration of the two...
10.
Lando D, Stevens T, Basu S, Laue E
Nucleus
. 2018 Feb;
9(1):190-201.
PMID: 29431585
Single-cell chromosome conformation capture approaches are revealing the extent of cell-to-cell variability in the organization and packaging of genomes. These single-cell methods, unlike their multi-cell counterparts, allow straightforward computation of...