Mehrdad Shamloo
Overview
Explore the profile of Mehrdad Shamloo including associated specialties, affiliations and a list of published articles.
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68
Citations
3925
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Recent Articles
1.
Santoro M, Lam R, Blumenfeld S, Tan W, Ciari P, Chu E, et al.
NPJ Parkinsons Dis
. 2025 Feb;
11(1):28.
PMID: 39934193
Efforts to develop disease-modifying treatments for Parkinson's disease (PD) have been hindered by the lack of animal models replicating all hallmarks of PD and the insufficient attention to extra-nigrostriatal regions...
2.
Evans A, Park H, Woods C, Lam R, Rijsketic D, Xu C, et al.
J Neuroinflammation
. 2024 Dec;
21(1):322.
PMID: 39696597
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse...
3.
Evans A, Park H, Woods C, Lam R, Rijsketic D, Xu C, et al.
Res Sq
. 2024 Nov;
PMID: 39574895
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse models...
4.
Santoro M, Lam R, Blumenfeld S, Tan W, Ciari P, Chu E, et al.
Res Sq
. 2024 Nov;
PMID: 39483924
Efforts to develop disease-modifying treatments for Parkinson's disease (PD) have been hindered by the lack of animal models replicating all hallmarks of PD and the insufficient attention to extra-nigrostriatal regions...
5.
Kantarci H, Elvira P, Thottumkara A, OConnell E, Iyer M, Donovan L, et al.
Cell
. 2024 Aug;
187(17):4690-4712.e30.
PMID: 39142281
Electrical excitability-the ability to fire and propagate action potentials-is a signature feature of neurons. How neurons become excitable during development and whether excitability is an intrinsic property of neurons remain...
6.
Evans A, Saw N, Woods C, Vidano L, Blumenfeld S, Lam R, et al.
Brain Behav Immun
. 2024 Feb;
118:334-354.
PMID: 38408498
Aging and age-related diseases are associated with cellular stress, metabolic imbalance, oxidative stress, and neuroinflammation, accompanied by cognitive impairment. Lifestyle factors such as diet, sleep fragmentation, and stress can potentiate...
7.
Bowen E, DiGiacomo P, Fraser H, Guttenplan K, Smith B, Heberling M, et al.
Discov Ment Health
. 2023 Nov;
3(1):27.
PMID: 38036718
Schizophrenia is a debilitating condition necessitating more efficacious therapies. Previous studies suggested that schizophrenia development is associated with aberrant synaptic pruning by glial cells. We pursued an interdisciplinary approach to...
8.
Matt R, Martin R, Evans A, Gever J, Vargas G, Shamloo M, et al.
Handb Exp Pharmacol
. 2023 Jul;
285:555-616.
PMID: 37495851
Adrenoceptors (ARs) throughout the brain are stimulated by noradrenaline originating mostly from neurons of the locus coeruleus, a brainstem nucleus that is ostensibly the earliest to show detectable pathology in...
9.
Shamloo S, Defensor E, Ciari P, Ogawa G, Vidano L, Lin J, et al.
Front Neurosci
. 2023 Apr;
17:1150156.
PMID: 37090796
There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is...
10.
Evans A, Defensor E, Shamloo M
Front Pharmacol
. 2022 Dec;
13:1030609.
PMID: 36532725
Locus coeruleus (LC) noradrenergic (NE) neurons supply the main adrenergic input to the forebrain. NE is a dual modulator of cognition and neuroinflammation. NE neurons of the LC are particularly...