Andrew K Evans
Overview
Explore the profile of Andrew K Evans including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1038
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Recent Articles
1.
Evans A, Park H, Woods C, Lam R, Rijsketic D, Xu C, et al.
J Neuroinflammation
. 2024 Dec;
21(1):322.
PMID: 39696597
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse...
2.
Evans A, Park H, Woods C, Lam R, Rijsketic D, Xu C, et al.
Res Sq
. 2024 Nov;
PMID: 39574895
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse models...
3.
Evans A, Saw N, Woods C, Vidano L, Blumenfeld S, Lam R, et al.
Brain Behav Immun
. 2024 Feb;
118:334-354.
PMID: 38408498
Aging and age-related diseases are associated with cellular stress, metabolic imbalance, oxidative stress, and neuroinflammation, accompanied by cognitive impairment. Lifestyle factors such as diet, sleep fragmentation, and stress can potentiate...
4.
Matt R, Martin R, Evans A, Gever J, Vargas G, Shamloo M, et al.
Handb Exp Pharmacol
. 2023 Jul;
285:555-616.
PMID: 37495851
Adrenoceptors (ARs) throughout the brain are stimulated by noradrenaline originating mostly from neurons of the locus coeruleus, a brainstem nucleus that is ostensibly the earliest to show detectable pathology in...
5.
Evans A, Defensor E, Shamloo M
Front Pharmacol
. 2022 Dec;
13:1030609.
PMID: 36532725
Locus coeruleus (LC) noradrenergic (NE) neurons supply the main adrenergic input to the forebrain. NE is a dual modulator of cognition and neuroinflammation. NE neurons of the LC are particularly...
6.
Evans A, Park H, Saw N, Singhal K, Ogawa G, Leib R, et al.
Neurobiol Aging
. 2021 Jul;
106:241-256.
PMID: 34320462
The locus coeruleus (LC) provides the primary noradrenergic input to the forebrain and hippocampus, and may be vulnerable to degeneration and contribute to age-related cognitive decline and neuroinflammation. Additionally, inhibition...
7.
Evans A, Ardestani P, Yi B, Park H, Lam R, Shamloo M
Neurobiol Dis
. 2020 Sep;
146:105089.
PMID: 32971233
Adrenergic systems regulate both cognitive function and immune function. The primary source of adrenergic signaling in the brain is norepinephrine (NE) neurons of the locus coeruleus (LC), which are vulnerable...
8.
Yi B, Jahangir A, Evans A, Briggs D, Ravina K, Ernest J, et al.
PLoS One
. 2017 Jul;
12(7):e0180319.
PMID: 28746336
The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathological features associated with Alzheimer's disease (AD). Evidence indicates that ADRB1 plays an...
9.
Ardestani P, Evans A, Yi B, Nguyen T, Coutellier L, Shamloo M
Neuropharmacology
. 2017 Jan;
116:371-386.
PMID: 28089846
Degeneration of noradrenergic neurons occurs at an early stage of Alzheimer's Disease (AD). The noradrenergic system regulates arousal and learning and memory, and has been implicated in regulating neuroinflammation. Loss...
10.
Yi B, Sahn J, Ardestani P, Evans A, Scott L, Chan J, et al.
J Neurochem
. 2016 Dec;
140(4):561-575.
PMID: 27926996
Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide beneficial effects for neurodegenerative diseases. Herein, we report the identification of a novel class of Sig2R ligands and...