Mehmet G Badur
Overview
Explore the profile of Mehmet G Badur including associated specialties, affiliations and a list of published articles.
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13
Citations
804
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Recent Articles
1.
Muthusamy T, Cordes T, Handzlik M, You L, Lim E, Gengatharan J, et al.
Nature
. 2020 Aug;
586(7831):790-795.
PMID: 32788725
Serine, glycine and other nonessential amino acids are critical for tumour progression, and strategies to limit their availability are emerging as potential therapies for cancer. However, the molecular mechanisms driving...
2.
Fu A, Alvarez-Perez J, Avizonis D, Kin T, Ficarro S, Choi D, et al.
Nat Metab
. 2020 Jul;
2(5):432-446.
PMID: 32694660
Chronic inflammation is linked to diverse disease processes, but the intrinsic mechanisms that determine cellular sensitivity to inflammation are incompletely understood. Here, we show the contribution of glucose metabolism to...
3.
Gantner M, Eade K, Wallace M, Handzlik M, Fallon R, Trombley J, et al.
N Engl J Med
. 2019 Sep;
381(15):1422-1433.
PMID: 31509666
Background: Identifying mechanisms of diseases with complex inheritance patterns, such as macular telangiectasia type 2, is challenging. A link between macular telangiectasia type 2 and altered serine metabolism has been...
4.
Reina-Campos M, Linares J, Duran A, Cordes T, LHermitte A, Badur M, et al.
Cancer Cell
. 2019 Mar;
35(3):385-400.e9.
PMID: 30827887
Increasingly effective therapies targeting the androgen receptor have paradoxically promoted the incidence of neuroendocrine prostate cancer (NEPC), the most lethal subtype of castration-resistant prostate cancer (PCa), for which there is...
5.
Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur M, et al.
Cell Rep
. 2019 Jan;
26(1):192-208.e6.
PMID: 30605676
The AMP-activated protein kinase (AMPK) is a highly conserved master regulator of metabolism, whose activation has been proposed to be therapeutically beneficial for the treatment of several metabolic diseases, including...
6.
Badur M, Muthusamy T, Parker S, Ma S, McBrayer S, Cordes T, et al.
Cell Rep
. 2018 Nov;
25(6):1680.
PMID: 30404018
No abstract available.
7.
Badur M, Muthusamy T, Parker S, Ma S, McBrayer S, Cordes T, et al.
Cell Rep
. 2018 Oct;
25(4):1018-1026.e4.
PMID: 30355481
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG) accumulation, the...
8.
Zhao D, Badur M, Luebeck J, Magana J, Birmingham A, Sasik R, et al.
Mol Cell
. 2018 Feb;
69(4):699-708.e7.
PMID: 29452643
The metabolic pathways fueling tumor growth have been well characterized, but the specific impact of transforming events on network topology and enzyme essentiality remains poorly understood. To this end, we...
9.
Badur M, Metallo C
Metab Eng
. 2017 Dec;
45:95-108.
PMID: 29199104
Metabolic dysfunction has reemerged as an essential hallmark of tumorigenesis, and metabolic phenotypes are increasingly being integrated into pre-clinical models of disease. The complexity of these metabolic networks requires systems-level...
10.
Zhang H, Badur M, Divakaruni A, Parker S, Jager C, Hiller K, et al.
Cell Rep
. 2016 Aug;
16(6):1536-1547.
PMID: 27477285
Recent studies have suggested that human pluripotent stem cells (hPSCs) depend primarily on glycolysis and only increase oxidative metabolism during differentiation. Here, we demonstrate that both glycolytic and oxidative metabolism...