Seth J Parker
Overview
Explore the profile of Seth J Parker including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
39
Citations
3775
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice
Johal A, Al-Shekaili H, Abedrabbo M, Kehinde A, Towriss M, Koe J, et al.
Cell Rep
. 2024 Dec;
43(12):115069.
PMID: 39661514
Lysine metabolism converges at α-aminoadipic semialdehyde dehydrogenase (ALDH7A1). Rare loss-of-function mutations in ALDH7A1 cause a toxic accumulation of lysine catabolites, including piperideine-6-carboxylate (P6C), that are thought to cause fatal seizures...
2.
Ali H, Karasinska J, Topham J, Johal D, Kalloger S, Metcalfe A, et al.
Cancer Metab
. 2024 Oct;
12(1):28.
PMID: 39363341
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes,...
3.
Koe J, Parker S
Curr Opin Biotechnol
. 2023 Dec;
85:103022.
PMID: 38056204
Amino acid transporters (AATs) facilitate nutrient uptake and nutrient exchange between cancer and stromal cells. The posttranslational modification (PTM) of transporters is an important mechanism that tumor-associated cells use to...
4.
Encarnacion-Rosado J, Sohn A, Biancur D, Lin E, Osorio-Vasquez V, Rodrick T, et al.
Nat Cancer
. 2023 Oct;
5(1):85-99.
PMID: 37814010
Pancreatic ductal adenocarcinoma (PDAC) cells use glutamine (Gln) to support proliferation and redox balance. Early attempts to inhibit Gln metabolism using glutaminase inhibitors resulted in rapid metabolic reprogramming and therapeutic...
5.
Venkateswaran G, McDonald P, Chafe S, Brown W, Gerbec Z, Awrey S, et al.
Mol Cancer Ther
. 2023 Jun;
22(10):1228-1242.
PMID: 37348875
The ability of tumor cells to alter their metabolism to support survival and growth presents a challenge to effectively treat cancers. Carbonic anhydrase IX (CAIX) is a hypoxia-induced, metabolic enzyme...
6.
Zhao Z, Khurana A, Antony F, Young J, Hewton K, Brough Z, et al.
Mol Cell Proteomics
. 2023 Jun;
22(8):100588.
PMID: 37295717
Membrane proteins play critical roles at the cell surface and their misfunction is a hallmark of many human diseases. A precise evaluation of the plasma membrane proteome is therefore essential...
7.
Koe J, Hewton K, Parker S
Mol Cell
. 2022 Sep;
82(17):3121-3123.
PMID: 36055205
In this issue of Molecular Cell, Ali et al. (2022) show that bicarbonate uptake by SLC4A7 fuels de novo nucleotide synthesis and cell proliferation and is regulated by mTORC1.
8.
Martino C, Zaramela L, Gao B, Embree M, Tarasova J, Parker S, et al.
Nat Commun
. 2022 Aug;
13(1):4630.
PMID: 35941112
Liver damage due to chronic alcohol use is among the most prevalent liver diseases. Alcohol consumption frequency is a strong factor of microbiota variance. Here we use isotope labeled [1-C]...
9.
Kehinde A, Parker S
Cancer Res
. 2022 May;
82(9):1695-1697.
PMID: 35502550
Metabolic rewiring in cancer cells supports many aspects of tumor growth. Understanding the mechanisms that result in metabolic rewiring, such as altered enzyme expression, is key to identifying therapeutic vulnerabilities...
10.
Zhang H, Geltink R, Parker S, Sorensen P
Trends Cell Biol
. 2022 Apr;
32(9):800-814.
PMID: 35365367
Cysteine, a thiol-containing amino acid, is crucial for the synthesis of sulfur-containing biomolecules that control multiple essential cellular activities. Altered cysteine metabolism has been linked to numerous driver oncoproteins and...