Megan S Keiser
Overview
Explore the profile of Megan S Keiser including associated specialties, affiliations and a list of published articles.
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18
Citations
541
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Recent Articles
1.
Jackson R, Keiser M, Meltzer J, Fykstra D, Dierksmeier S, Hajizadeh S, et al.
Mol Ther
. 2024 Mar;
32(5):1373-1386.
PMID: 38504517
Epidemiological studies show that individuals who carry the relatively uncommon APOE ε2 allele rarely develop Alzheimer disease, and if they do, they have a later age of onset, milder clinical...
2.
Jackson R, Keiser M, Meltzer J, Fykstra D, Dierksmeier S, Melloni A, et al.
bioRxiv
. 2023 Aug;
PMID: 37645718
One Sentence Summary: Introduction of ApoE2 using an AAV that transduces the ependymal cells of the ventricle causes a reduction in amyloid load and plaque associated synapse loss, and reduces...
3.
Carrell E, Chen Y, Ranum P, Coffin S, Singh L, Tecedor L, et al.
Mol Ther Nucleic Acids
. 2023 Aug;
33:296-304.
PMID: 37547292
Recombinant adeno-associated viral vectors (rAAVs) are a promising strategy to treat neurodegenerative diseases because of their ability to infect non-dividing cells and confer long-term transgene expression. Despite an ever-growing library...
4.
Ranum P, Tecedor L, Keiser M, Chen Y, Leib D, Liu X, et al.
Mol Ther
. 2023 Jan;
31(3):609-612.
PMID: 36610400
No abstract available.
5.
Carrell E, Keiser M, Robbins A, Davidson B
Mol Ther Methods Clin Dev
. 2022 May;
25:333-343.
PMID: 35573049
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease caused by a (CAG) repeat expansion in the coding sequence of . The primary mechanism of disease in SCA1...
6.
Keiser M, Ranum P, Yrigollen C, Carrell E, Smith G, Muehlmatt A, et al.
Nat Med
. 2021 Oct;
27(11):1982-1989.
PMID: 34663988
RNA interference (RNAi) for spinocerebellar ataxia type 1 can prevent and reverse behavioral deficits and neuropathological readouts in mouse models, with safety and benefit lasting over many months. The RNAi...
7.
Chen Y, Keiser M, Davidson B
Curr Protoc Mouse Biol
. 2018 Nov;
8(4):e56.
PMID: 30489697
Adeno-associated virus (AAV) vectors are exemplary tools for studying gene function in vivo and are particularly favorable for transferring genes of interest into brain tissues. They have shown great promise...
8.
Chen Y, Keiser M, Davidson B
Curr Protoc Mouse Biol
. 2018 Nov;
8(4):e58.
PMID: 30485696
Viral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into...
9.
Keiser M, Chen Y, Davidson B
Curr Protoc Mouse Biol
. 2018 Nov;
8(4):e57.
PMID: 30395418
Stereotaxic intracranial injection of viral vectors is a valuable technique to directly deliver genetic material to a specific population of cells in the central nervous system of a mouse model....
10.
Cheng C, Spengler R, Keiser M, Monteys A, Rieders J, Ramachandran S, et al.
Hum Mol Genet
. 2018 Sep;
27(24):4303-4314.
PMID: 30239724
Polyglutamine (polyQ) repeat diseases are a class of neurodegenerative disorders caused by CAG-repeat expansion. There are diverse cellular mechanisms behind the pathogenesis of polyQ disorders, including transcriptional dysregulation. Interestingly, we...