Megan N Michalski
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Explore the profile of Megan N Michalski including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
244
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Recent Articles
1.
Yue F, Ku A, Stevens P, Michalski M, Jiang W, Tu J, et al.
bioRxiv
. 2024 Jan;
PMID: 38260423
ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination...
2.
Diegel C, Michalski M, Williams B
MicroPubl Biol
. 2023 Nov;
2023.
PMID: 37908496
The requirement for LRP5 and LRP6 to prevent β-catenin degradation in the absence of the tumor suppressor APC is unclear because cell culture models have yielded conflicting results. We previously...
3.
Michalski M, Williams B
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759711
The ability to create genetically engineered mouse models (GEMMs) has exponentially increased our understanding of many areas of biology. Musculoskeletal biology is no exception. In this review, we will first...
4.
Craig S, Michalski M, Williams B
Curr Top Dev Biol
. 2023 Mar;
153:327-346.
PMID: 36967199
WNT signaling, essential for many aspects of development, is among the most commonly altered pathways associated with human disease. While initially studied in cancer, dysregulation of WNT signaling has been...
5.
Liegel R, Michalski M, Vaidya S, Bittermann E, Finnerty E, Menke C, et al.
Development
. 2023 Feb;
150(3).
PMID: 36789910
Frizzled 2 (FZD2) is a transmembrane Wnt receptor. We previously identified a pathogenic human FZD2 variant in individuals with FZD2-associated autosomal dominant Robinow syndrome. The variant encoded a protein with...
6.
Koh A, Kyung Nam H, Michalski M, Do J, McCauley L, Hatch N
Osteoporos Int
. 2022 Jul;
33(11):2423-2433.
PMID: 35871207
Introduction: Hypophosphatasia is the rare heritable disorder caused by mutations in the tissue non-specific alkaline phosphatase (TNAP) enzyme leading to TNAP deficiency. Individuals with hypophosphatasia commonly present with bone hypomineralization...
7.
Zhong Z, Michalski M, Stevens P, Sall E, Williams B
J Biol Chem
. 2021 May;
296:100782.
PMID: 34000297
Hyperactivation of Wnt/β-catenin (canonical) signaling in colorectal cancers (CRCs) was identified in the 1990s. Most CRC patients have mutations in genes that encode components of the Wnt pathway. Inactivating mutations...
8.
Kushwaha P, Kim S, Foxa G, Michalski M, Williams B, Tomlinson R, et al.
J Cell Physiol
. 2020 Jan;
235(10):6673-6683.
PMID: 31985040
The activation of the Wnt/β-catenin signaling pathway is critical for skeletal development but surprisingly little is known about the requirements for the specific frizzled (Fzd) receptors that recognize Wnt ligands....
9.
Michalski M, Williams B
J Biol Chem
. 2018 Jun;
293(24):9542-9543.
PMID: 29907733
Alterations in the gene are a putative cause of Paget's disease of bone, yet results are conflicting about how these mutations impact osteoclasts, the cell type believed to be the...
10.
Michalski M, Seydel A, Siismets E, Zweifler L, Koh A, Sinder B, et al.
FASEB J
. 2018 Feb;
32(7):3730-3741.
PMID: 29475373
A prolonged increase in proinflammatory cytokines is associated with osteoporotic and autoimmune bone loss and, conversely, anti-inflammatory pathways are associated with protection against bone loss. Milk fat globule-epidermal growth factor...