Megan Files
Overview
Explore the profile of Megan Files including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
148
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0
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Recent Articles
1.
Kumar A, Chettiar S, Brown B, Early J, Ollinger J, Files M, et al.
Sci Rep
. 2022 Sep;
12(1):14879.
PMID: 36050506
We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000 compounds from the AbbVie corporate collection and identified 24 chemotypes with...
2.
Clapacs Z, ONeill C, Shrimali P, Lokhande G, Files M, Kim D, et al.
Biomacromolecules
. 2022 Feb;
23(3):1183-1194.
PMID: 35170303
Alginate hydrogels are widely used for tissue engineering and regenerative medicine due to their excellent biocompatibility. A facile and commonly used strategy to crosslink alginate is the addition of Ca...
3.
Fan X, Xu J, Files M, Cirillo J, Endsley J, Zhou J, et al.
Tuberculosis (Edinb)
. 2019 May;
116S:S28-S33.
PMID: 31080089
The human immunodeficiency virus (HIV) pandemic is driving the re-emergence of tuberculosis (TB) as a global health threat, both by increasing the susceptibility of HIV-infected people to infection with Mycobacterium...
4.
Odingo J, Early J, Smith J, Johnson J, Bailey M, Files M, et al.
Drug Dev Res
. 2019 Mar;
80(5):566-572.
PMID: 30893501
There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8-hydroxyquinoline series is a privileged scaffold with anticancer, antifungal, and antibacterial activities....
5.
Madu I, Files M, Gharaibeh D, Moore A, Jung K, Gowen B, et al.
PLoS Pathog
. 2018 Dec;
14(12):e1007439.
PMID: 30576397
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West...
6.
Bonnett S, Dennison D, Files M, Bajpai A, Parish T
PLoS One
. 2018 Oct;
13(10):e0198059.
PMID: 30332412
There is an urgent need for the development of shorter, simpler and more tolerable drugs to treat antibiotic tolerant populations of Mycobacterium tuberculosis. We previously identified a series of hydrazones...
7.
Melief E, Kokoczka R, Files M, Bailey M, Alling T, Li H, et al.
Biol Methods Protoc
. 2018 Sep;
3(1):bpy009.
PMID: 30197930
There is a pressing need to develop novel anti-tubercular drugs. High-throughput phenotypic screening yields chemical series that inhibit bacterial growth. Target identification for such series is challenging, but necessary for...
8.
Odingo J, Bailey M, Files M, Early J, Alling T, Dennison D, et al.
ACS Omega
. 2018 Jul;
2(9):5873-5890.
PMID: 30023755
Nitazoxanide has antiparasitic and antibiotic activities including activity against . We prepared and evaluated a set of its analogues to determine the structure-activity relationship, and identified several amide- and urea-based...
9.
Bonnett S, Ollinger J, Chandrasekera S, Florio S, OMalley T, Files M, et al.
ACS Infect Dis
. 2016 Sep;
2(12):893-902.
PMID: 27642770
The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase...
10.
Early J, Casey A, Martinez-Grau M, Gonzalez Valcarcel I, Vieth M, Ollinger J, et al.
Antimicrob Agents Chemother
. 2016 Apr;
60(6):3608-16.
PMID: 27044545
Mycobacterium tuberculosis is a global pathogen of huge importance which can adapt to several host niche environments in which carbon source availability is likely to vary. We developed and ran...