Juliane Ollinger
Overview
Explore the profile of Juliane Ollinger including associated specialties, affiliations and a list of published articles.
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18
Citations
527
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Recent Articles
1.
Kumar A, Chettiar S, Brown B, Early J, Ollinger J, Files M, et al.
Sci Rep
. 2022 Sep;
12(1):14879.
PMID: 36050506
We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000 compounds from the AbbVie corporate collection and identified 24 chemotypes with...
2.
Odingo J, Early J, Smith J, Johnson J, Bailey M, Files M, et al.
Drug Dev Res
. 2019 Mar;
80(5):566-572.
PMID: 30893501
There is an urgent need for new treatments effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. The 8-hydroxyquinoline series is a privileged scaffold with anticancer, antifungal, and antibacterial activities....
3.
Ollinger J, Kumar A, Roberts D, Bailey M, Casey A, Parish T
PLoS One
. 2019 Jan;
14(1):e0205479.
PMID: 30650074
Tuberculosis is a disease of global importance for which novel drugs are urgently required. We developed a whole-cell phenotypic screen which can be used to identify inhibitors of Mycobacterium tuberculosis...
4.
Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, et al.
ACS Infect Dis
. 2018 Dec;
5(2):272-280.
PMID: 30501173
To find new inhibitors of Mycobacterium tuberculosis that have novel mechanisms of action, we miniaturized a high throughput screen to identify compounds that disrupt pH homeostasis. We adapted and validated...
5.
Bonnett S, Ollinger J, Chandrasekera S, Florio S, OMalley T, Files M, et al.
ACS Infect Dis
. 2016 Sep;
2(12):893-902.
PMID: 27642770
The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase...
6.
Early J, Casey A, Martinez-Grau M, Gonzalez Valcarcel I, Vieth M, Ollinger J, et al.
Antimicrob Agents Chemother
. 2016 Apr;
60(6):3608-16.
PMID: 27044545
Mycobacterium tuberculosis is a global pathogen of huge importance which can adapt to several host niche environments in which carbon source availability is likely to vary. We developed and ran...
7.
Chandrasekera N, Alling T, Bailey M, Files M, Early J, Ollinger J, et al.
J Med Chem
. 2015 Aug;
58(18):7273-85.
PMID: 26295286
We conducted an evaluation of the phenoxyalkylbenzimidazole series based on the exemplar 2-ethyl-1-(3-phenoxypropyl)-1H-benzo[d]imidazole for its antitubercular activity. Four segments of the molecule were examined systematically to define a structure-activity relationship...
8.
Moraski G, Miller P, Bailey M, Ollinger J, Parish T, Boshoff H, et al.
ACS Infect Dis
. 2015 May;
1(2):85-90.
PMID: 25984566
Zolpidem (Ambien, ) is an imidazo[1,2-]pyridine-3-acetamide and an approved drug for the treatment of insomnia. As medicinal chemists enamored by how structure imparts biological function, we found it to have...
9.
Odingo J, OMalley T, Kesicki E, Alling T, Bailey M, Early J, et al.
Bioorg Med Chem
. 2014 Dec;
22(24):6965-79.
PMID: 25456390
The 2,4-diaminoquinazoline class of compounds has previously been identified as an effective inhibitor of Mycobacterium tuberculosis growth. We conducted an extensive evaluation of the series for its potential as a...
10.
Chandrasekera N, Bailey M, Files M, Alling T, Florio S, Ollinger J, et al.
PeerJ
. 2014 Oct;
2:e612.
PMID: 25320680
We demonstrated that the 3-substituted benzothiophene-1,1-dioxide class of compounds are effective inhibitors of Mycobacterium tuberculosis growth under aerobic conditions. We examined substitution at the C-3 position of the benzothiophene-1,1-dioxide series...