McKenzie L Shaw
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Explore the profile of McKenzie L Shaw including associated specialties, affiliations and a list of published articles.
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9
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2391
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Recent Articles
1.
Liu I, Cruzeiro G, Bjerke L, Rogers R, Grabovska Y, Beck A, et al.
Cancer Cell
. 2024 Sep;
PMID: 39232581
Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors lacking targeted therapies. They originate from interneuronal precursors; however, leveraging this origin for therapeutic insights remains unexplored. Here, we delineate a...
2.
Liu I, Jiang L, Samuelsson E, Marco Salas S, Beck A, Hack O, et al.
Nat Genet
. 2022 Dec;
54(12):1881-1894.
PMID: 36471067
Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity at different ages...
3.
Panditharatna E, Marques J, Wang T, Trissal M, Liu I, Jiang L, et al.
Cancer Discov
. 2022 Oct;
12(12):2880-2905.
PMID: 36305736
Significance: Epigenetic dysregulation is at the core of H3K27M-glioma tumorigenesis. Here, we identify the BRG1-BAF complex as a critical regulator of enhancer and transcription factor landscapes, which maintain H3K27M glioma...
4.
Gojo J, Englinger B, Jiang L, Hubner J, Shaw M, Hack O, et al.
Cancer Cell
. 2020 Jul;
38(1):44-59.e9.
PMID: 32663469
Ependymoma is a heterogeneous entity of central nervous system tumors with well-established molecular groups. Here, we apply single-cell RNA sequencing to analyze ependymomas across molecular groups and anatomic locations to...
5.
Hovestadt V, Smith K, Bihannic L, Filbin M, Shaw M, Baumgartner A, et al.
Nature
. 2019 Jul;
572(7767):74-79.
PMID: 31341285
Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well defined, the extent to which cellular diversity underlies their...
6.
Neftel C, Laffy J, Filbin M, Hara T, Shore M, Rahme G, et al.
Cell
. 2019 Jul;
178(4):835-849.e21.
PMID: 31327527
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains challenging. Here, we use an integrative approach spanning single-cell RNA-sequencing of...
7.
Filbin M, Tirosh I, Hovestadt V, Shaw M, Escalante L, Mathewson N, et al.
Science
. 2018 Apr;
360(6386):331-335.
PMID: 29674595
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis....
8.
Tang Q, Iyer S, Lobbardi R, Moore J, Chen H, Lareau C, et al.
J Exp Med
. 2017 Sep;
214(10):2875-2887.
PMID: 28878000
Recent advances in single-cell, transcriptomic profiling have provided unprecedented access to investigate cell heterogeneity during tissue and organ development. In this study, we used massively parallel, single-cell RNA sequencing to...
9.
Venteicher A, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin M, et al.
Science
. 2017 Apr;
355(6332).
PMID: 28360267
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these influences in isocitrate dehydrogenase (IDH)-mutant...