Ryan A Flynn
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Explore the profile of Ryan A Flynn including associated specialties, affiliations and a list of published articles.
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78
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11425
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Recent Articles
1.
Floyd B, Schmidt E, Till N, Yang J, Liao P, George B, et al.
bioRxiv
. 2025 Mar;
PMID: 40027624
The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven by aberrant cell surface...
2.
Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko C, et al.
Cell
. 2025 Feb;
PMID: 40020667
The composition and organization of the cell surface determine how cells interact with their environment. Traditionally, glycosylated transmembrane proteins were thought to be the major constituents of the external surface...
3.
Jung J, Schmidt E, Chang H, Jame-Chenarboo Z, Enterina J, McCord K, et al.
ACS Chem Biol
. 2025 Jan;
20(2):386-400.
PMID: 39836965
Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec-glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovered, but the class...
4.
Ducoli L, Zarnegar B, Porter D, Meyers R, Miao W, Riley N, et al.
bioRxiv
. 2024 Oct;
PMID: 39386644
RNA binding proteins ( RBPs ) control varied processes, including RNA splicing, stability, transport, and translation . Dysfunctional RNA-RBP interactions contribute to the pathogenesis of human disease , however, characterizing...
5.
Porat J, Watkins C, Jin C, Xie X, Tan X, Lebedenko C, et al.
bioRxiv
. 2024 Sep;
PMID: 39257776
There is an increasing appreciation for the role of cell surface glycans in modulating interactions with extracellular ligands and participating in intercellular communication. We recently reported the existence of sialoglycoRNAs,...
6.
Xie Y, Chai P, Till N, Hemberger H, Lebedenko C, Porat J, et al.
Cell
. 2024 Aug;
187(19):5228-5237.e12.
PMID: 39173631
GlycoRNA consists of RNAs modified with secretory N-glycans that are presented on the cell surface. Although previous work supported a covalent linkage between RNA and glycans, the direct chemical nature...
7.
Zheng R, Dunlap M, Bobkov G, Gonzalez-Figueroa C, Patel K, Lyu J, et al.
Mol Cell
. 2024 May;
84(11):2087-2103.e8.
PMID: 38815579
RNA splicing is pivotal in post-transcriptional gene regulation, yet the exponential expansion of intron length in humans poses a challenge for accurate splicing. Here, we identify hnRNPM as an essential...
8.
Kageler L, Perr J, Flynn R
Cell Chem Biol
. 2024 May;
31(6):1132-1144.
PMID: 38772372
Proximity is a fundamental concept in chemistry and biology, referring to the convergence of molecules to facilitate new molecular interactions or reactions. Hybrid biopolymers like glycosylphosphatidylinositol (GPI)-anchored proteins, ubiquitinated proteins,...
9.
Xie Y, Liu X, Zhao C, Chen S, Wang S, Lin Z, et al.
bioRxiv
. 2024 Apr;
PMID: 38559279
Glycans modify protein, lipid, and even RNA molecules to form the regulatory outer coat on cells called the glycocalyx. The changes in glycosylation have been linked to the initiation and...
10.
Aryan F, Detres D, Luo C, Kim S, Shah A, Bartusel M, et al.
Mol Cell
. 2023 Nov;
83(23):4413-4423.e10.
PMID: 37979585
DEAD-box ATPases are major regulators of biomolecular condensates and orchestrate diverse biochemical processes that are critical for the functioning of cells. How DEAD-box proteins are selectively recruited to their respective...