Maurice Darding
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Explore the profile of Maurice Darding including associated specialties, affiliations and a list of published articles.
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12
Citations
1634
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Recent Articles
1.
Liccardi G, Garcia L, Tenev T, Annibaldi A, Legrand A, Robertson D, et al.
Mol Cell
. 2019 Jan;
73(3):413-428.e7.
PMID: 30598363
Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and inflammation. Here, we...
2.
Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, et al.
Nat Commun
. 2018 Sep;
9(1):3910.
PMID: 30254289
The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene activation and to prevent cell death induced by TNF. Here, we...
3.
Peltzer N, Darding M, Montinaro A, Draber P, Draberova H, Kupka S, et al.
Nature
. 2018 Apr;
557(7703):112-117.
PMID: 29695863
The linear ubiquitin chain assembly complex (LUBAC) is required for optimal gene activation and prevention of cell death upon activation of immune receptors, including TNFR1 . Deficiency in the LUBAC...
4.
Teh C, Lalaoui N, Jain R, Policheni A, Heinlein M, Alvarez-Diaz S, et al.
Nat Commun
. 2016 Nov;
7:13353.
PMID: 27857075
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC...
5.
Zinngrebe J, Rieser E, Taraborrelli L, Peltzer N, Hartwig T, Ren H, et al.
J Exp Med
. 2016 Nov;
213(12):2671-2689.
PMID: 27810922
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain-interacting protein (SHARPIN), heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), and HOIL-1-interacting protein (HOIP), is a critical regulator of inflammation and immunity....
6.
Dondelinger Y, Darding M, Bertrand M, Walczak H
Cell Mol Life Sci
. 2016 Apr;
73(11-12):2165-76.
PMID: 27066894
Tumor necrosis factor (TNF) is a master pro-inflammatory cytokine, and inappropriate TNF signaling is implicated in the pathology of many inflammatory diseases. Ligation of TNF to its receptor TNFR1 induces...
7.
Peltzer N, Darding M, Walczak H
Trends Cell Biol
. 2016 Feb;
26(6):445-461.
PMID: 26877205
The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway. TNF signaling can result in different biological...
8.
Rickard J, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, et al.
Elife
. 2014 Dec;
3.
PMID: 25443632
SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm mutation causes TNF-dependent multi-organ...
9.
Peltzer N, Rieser E, Taraborrelli L, Draber P, Darding M, Pernaute B, et al.
Cell Rep
. 2014 Oct;
9(1):153-165.
PMID: 25284787
Linear ubiquitination is crucial for innate and adaptive immunity. The linear ubiquitin chain assembly complex (LUBAC), consisting of HOIL-1, HOIP, and SHARPIN, is the only known ubiquitin ligase that generates...
10.
Linkermann A, Brasen J, Darding M, Jin M, Sanz A, Heller J, et al.
Proc Natl Acad Sci U S A
. 2013 Jul;
110(29):12024-9.
PMID: 23818611
Regulated necrosis (RN) may result from cyclophilin (Cyp)D-mediated mitochondrial permeability transition (MPT) and receptor-interacting protein kinase (RIPK)1-mediated necroptosis, but it is currently unclear whether there is one common pathway in...