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Henning Walczak

Explore the profile of Henning Walczak including associated specialties, affiliations and a list of published articles. Areas
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Articles 151
Citations 12557
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Recent Articles
1.
Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez L, et al.
J Cancer Res Clin Oncol . 2024 Nov; 150(11):496. PMID: 39542886
Purpose: Small cell lung cancer (SCLC) has an extremely poor prognosis. Despite high initial response rates to chemotherapy and modest survival improvements with the addition of immune checkpoint inhibitors (ICI),...
2.
Ruiz Seco M, Pardo J, Schoergenhofer C, Dings C, Lehr T, Herth F, et al.
EClinicalMedicine . 2024 Nov; 77:102879. PMID: 39513186
Background: The phase 2 ASUNCTIS study assessed the efficacy and safety of asunercept, a fully human CD95 (Fas) ligand-binding protein, in hospitalised patients with moderate-to-severe coronavirus disease (COVID-19) to assess...
3.
Kabiljo J, Theophil A, Homola J, Renner A, Sturzenbecher N, Ammon D, et al.
J Immunother Cancer . 2024 Nov; 12(11). PMID: 39500527
Background: Patient-derived colorectal cancer (CRC) organoids (PDOs) solely consisting of malignant cells led to major advances in the understanding of cancer treatments. Yet, a major limitation is the absence of...
4.
Chen Y, Rieser E, Bhamra A, Surinova S, Kreuzaler P, Ho M, et al.
Cell Death Differ . 2024 Aug; 31(10):1267-1284. PMID: 39215104
Lymphotoxin β receptor (LTβR), a member of the TNF receptor superfamily (TNFR-SF), is essential for development and maturation of lymphoid organs. In addition, LTβR activation promotes carcinogenesis by inducing a...
5.
Veli O, Kaya O, Varanda A, Hildebrandt X, Xiao P, Estornes Y, et al.
Mol Metab . 2024 Jul; 87:101988. PMID: 39004142
Objective: Receptor-interacting protein kinase 1 (RIPK1) orchestrates the decision between cell survival and cell death in response to tumor necrosis factor (TNF) and other cytokines. Whereas the scaffolding function of...
6.
Kelepouras K, Saggau J, Varanda A, Zrilic M, Kiefer C, Rakhsh-Khorshid H, et al.
Cell Death Differ . 2024 May; 31(7):897-909. PMID: 38783091
Necroptosis is a caspase-independent modality of cell death implicated in many inflammatory pathologies. The execution of this pathway requires the formation of a cytosolic platform that comprises RIPK1 and RIPK3...
7.
Oda H, Manthiram K, Pimpale Chavan P, Rieser E, Veli O, Kaya O, et al.
Nat Immunol . 2024 Apr; 25(5):764-777. PMID: 38609546
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation...
8.
Albert M, Uranga-Murillo I, Arias M, de Miguel D, Pena N, Montinaro A, et al.
Cell Death Differ . 2024 Mar; 31(5):544-557. PMID: 38514848
The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this...
9.
Vringer E, Heilig R, Riley J, Black A, Cloix C, Skalka G, et al.
EMBO J . 2024 Feb; 43(6):904-930. PMID: 38337057
Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been shown to...
10.
Teague H, Lefevre C, Rieser E, Wolfram L, de Miguel D, Patricio de Oliveira D, et al.
Cell Death Differ . 2023 Nov; 31(1):28-39. PMID: 38001254
The ability of cells to mount an interferon response to virus infections depends on intracellular nucleic acid sensing pattern recognition receptors (PRRs). RIG-I is an intracellular PRR that binds short...