Lucia Taraborrelli
Overview
Explore the profile of Lucia Taraborrelli including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
1118
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Recent Articles
1.
Taraborrelli L, Senbabaoglu Y, Wang L, Lim J, Blake K, Kljavin N, et al.
Nat Commun
. 2023 Sep;
14(1):5945.
PMID: 37741832
Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve MSS-CRC patient outcomes. Here, we demonstrate that high tumor expression of...
2.
Capietto A, Jhunjhunwala S, Pollock S, Lupardus P, Wong J, Hansch L, et al.
J Exp Med
. 2020 Jan;
217(4).
PMID: 31940002
Tumor-specific mutations can generate neoantigens that drive CD8 T cell responses against cancer. Next-generation sequencing and computational methods have been successfully applied to identify mutations and predict neoantigens. However, only...
3.
Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, et al.
Nat Commun
. 2018 Sep;
9(1):3910.
PMID: 30254289
The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene activation and to prevent cell death induced by TNF. Here, we...
4.
Peltzer N, Darding M, Montinaro A, Draber P, Draberova H, Kupka S, et al.
Nature
. 2018 Apr;
557(7703):112-117.
PMID: 29695863
The linear ubiquitin chain assembly complex (LUBAC) is required for optimal gene activation and prevention of cell death upon activation of immune receptors, including TNFR1 . Deficiency in the LUBAC...
5.
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al.
Nat Cell Biol
. 2017 Aug;
19(9):1116-1129.
PMID: 28846096
Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity. Caspase activity can also have...
6.
Lafont E, Kantari-Mimoun C, Draber P, de Miguel D, Hartwig T, Reichert M, et al.
EMBO J
. 2017 Mar;
36(9):1147-1166.
PMID: 28258062
The linear ubiquitin chain assembly complex (LUBAC) is the only known E3 ubiquitin ligase which catalyses the generation of linear ubiquitin linkages LUBAC is a crucial component of various immune...
7.
Hartwig T, Montinaro A, von Karstedt S, Sevko A, Surinova S, Chakravarthy A, et al.
Mol Cell
. 2017 Feb;
65(4):730-742.e5.
PMID: 28212753
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known for specifically killing cancer cells, whereas in resistant cancers, TRAIL/TRAIL-R can promote metastasis via Rac1 and PI3K. It remains unknown, however,...
8.
Zinngrebe J, Rieser E, Taraborrelli L, Peltzer N, Hartwig T, Ren H, et al.
J Exp Med
. 2016 Nov;
213(12):2671-2689.
PMID: 27810922
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain-interacting protein (SHARPIN), heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), and HOIL-1-interacting protein (HOIP), is a critical regulator of inflammation and immunity....
9.
Corrado M, Mariotti F, Trapani L, Taraborrelli L, Nazio F, Cianfanelli V, et al.
EMBO J
. 2016 Jul;
35(16):1793-809.
PMID: 27390127
Mitochondrial dynamics and functionality are linked to the autophagic degradative pathway under several stress conditions. However, the interplay between mitochondria and autophagy upon cell death signalling remains unclear. The T-cell...
10.
Draber P, Kupka S, Reichert M, Draberova H, Lafont E, de Miguel D, et al.
Cell Rep
. 2015 Dec;
13(10):2258-72.
PMID: 26670046
Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases...