Mattijs M Heemskerk
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Explore the profile of Mattijs M Heemskerk including associated specialties, affiliations and a list of published articles.
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11
Citations
244
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Recent Articles
1.
Janssens S, Heemskerk M, van den Berg S, van Riel N, Nicolay K, Willems van Dijk K, et al.
Nutr Metab (Lond)
. 2015 Dec;
12:57.
PMID: 26691906
Background: Excess consumption of energy-dense, high-fat Western diets contributes to the development of obesity and obesity-related disorders, such as fatty liver disease. However, not only the quantity but also the...
2.
van Beek L, Vroegrijk I, Katiraei S, Heemskerk M, van Dam A, Kooijman S, et al.
Obesity (Silver Spring)
. 2015 Nov;
23(12):2435-44.
PMID: 26523352
Objective: Pathogenic immunoglobulins are produced during the development of obesity and contribute to the development of insulin resistance (IR). However, the mechanisms by which these antibodies affect IR are largely...
3.
Heemskerk M, Giera M, El Bouazzaoui F, Lips M, Pijl H, Willems van Dijk K, et al.
Nutrients
. 2015 Sep;
7(9):7676-90.
PMID: 26378572
Obese women with type 2 diabetes mellitus (T2DM) have more inflammation in their subcutaneous white adipose tissue (sWAT) than age-and-BMI similar obese women with normal glucose tolerance (NGT). We aimed...
4.
Heemskerk M, van Harmelen V, Willems van Dijk K, van Klinken J
Eur J Hum Genet
. 2015 May;
24(1):142-5.
PMID: 26014429
The assignment of causative genes to noncoding variants identified in genome-wide association studies (GWASs) is challenging. We show how combination of knowledge from gene and pathway databases and chromatin interaction...
5.
Hussaarts L, Garcia-Tardon N, van Beek L, Heemskerk M, Haeberlein S, van der Zon G, et al.
FASEB J
. 2015 Apr;
29(7):3027-39.
PMID: 25852044
Chronic low-grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short-lived infection with...
6.
van Dam A, Nahon K, Kooijman S, van den Berg S, Kanhai A, Kikuchi T, et al.
Diabetes
. 2014 Dec;
64(5):1544-54.
PMID: 25475439
Salsalate improves glucose intolerance and dyslipidemia in type 2 diabetes patients, but the mechanism is still unknown. The aim of the current study was to unravel the molecular mechanisms involved...
7.
Heemskerk M, Dharuri H, van den Berg S, Jonasdottir H, Kloos D, Giera M, et al.
J Lipid Res
. 2014 Oct;
55(12):2532-40.
PMID: 25320342
Prolonged niacin treatment elicits beneficial effects on the plasma lipid and lipoprotein profile that is associated with a protective CVD risk profile. Acute niacin treatment inhibits nonesterified fatty acid release...
8.
Heemskerk M, van den Berg S, Pronk A, van Klinken J, Boon M, Havekes L, et al.
Am J Physiol Endocrinol Metab
. 2014 Jan;
306(7):E808-13.
PMID: 24473440
The lipid-lowering effect of niacin has been attributed to the inhibition of cAMP production in adipocytes, thereby inhibiting intracellular lipolysis and release of nonesterified fatty acids (NEFA) to the circulation....
9.
Kuhnast S, Louwe M, Heemskerk M, Pieterman E, van Klinken J, van den Berg S, et al.
PLoS One
. 2013 Jul;
8(6):e66467.
PMID: 23840481
Objective: Niacin potently lowers triglycerides, mildly decreases LDL-cholesterol, and largely increases HDL-cholesterol. Despite evidence for an atheroprotective effect of niacin from previous small clinical studies, the large outcome trials, AIM-HIGH...
10.
van den Berg S, Heemskerk M, Geerling J, van Klinken J, Schaap F, Bijland S, et al.
FASEB J
. 2013 May;
27(8):3354-62.
PMID: 23650188
Mutations in apolipoprotein A5 (APOA5) have been associated with hypertriglyceridemia in humans and mice. This has been attributed to a stimulating role for APOA5 in lipoprotein lipase-mediated triglyceride hydrolysis and...