Matthias Muhar
Overview
Explore the profile of Matthias Muhar including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
2004
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0
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Recent Articles
1.
Farnung J, Muhar M, Liang J, Tolmachova K, Benoit R, Corn J, et al.
ACS Cent Sci
. 2023 May;
9(5):1025-1034.
PMID: 37252361
Macroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy are often achieved through the presence of short peptide sequences called LC3 interacting regions...
2.
Diesch J, Le Pannerer M, Winkler R, Casquero R, Muhar M, van der Garde M, et al.
Nat Commun
. 2021 Oct;
12(1):6060.
PMID: 34663789
The nucleotide analogue azacitidine (AZA) is currently the best treatment option for patients with high-risk myelodysplastic syndromes (MDS). However, only half of treated patients respond and of these almost all...
3.
Endres T, Solvie D, Heidelberger J, Andrioletti V, Baluapuri A, Ade C, et al.
Mol Cell
. 2021 Jan;
81(4):830-844.e13.
PMID: 33453168
The MYC oncoprotein globally affects the function of RNA polymerase II (RNAPII). The ability of MYC to promote transcription elongation depends on its ubiquitylation. Here, we show that MYC and...
4.
Thiecke M, Wutz G, Muhar M, Tang W, Bevan S, Malysheva V, et al.
Cell Rep
. 2020 Jul;
32(3):107929.
PMID: 32698000
It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of...
5.
Liang J, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, et al.
Cell
. 2020 Mar;
180(6):1160-1177.e20.
PMID: 32160526
Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but is poorly understood beyond a few...
6.
Neumann T, Herzog V, Muhar M, von Haeseler A, Zuber J, Ameres S, et al.
BMC Bioinformatics
. 2019 May;
20(1):258.
PMID: 31109287
Background: Methods to read out naturally occurring or experimentally introduced nucleic acid modifications are emerging as powerful tools to study dynamic cellular processes. The recovery, quantification and interpretation of such...
7.
Skucha A, Ebner J, Schmollerl J, Roth M, Eder T, Cesar-Razquin A, et al.
Nat Commun
. 2018 May;
9(1):1983.
PMID: 29777171
MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. While studies of selected MLL-fusions have revealed critical...
8.
Muhar M, Ebert A, Neumann T, Umkehrer C, Jude J, Wieshofer C, et al.
Science
. 2018 Apr;
360(6390):800-805.
PMID: 29622725
Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. We combined SLAM-seq [thiol(SH)-linked alkylation for the metabolic sequencing of RNA],...
9.
Wutz G, Varnai C, Nagasaka K, Cisneros D, Stocsits R, Tang W, et al.
EMBO J
. 2017 Dec;
36(24):3573-3599.
PMID: 29217591
Mammalian genomes are spatially organized into compartments, topologically associating domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. How compartments, TADs, and loops are generated is unknown....
10.
Housden B, Muhar M, Gemberling M, Gersbach C, Stainier D, Seydoux G, et al.
Nat Rev Genet
. 2016 Nov;
18(1):24-40.
PMID: 27795562
Our understanding of the genetic mechanisms that underlie biological processes has relied extensively on loss-of-function (LOF) analyses. LOF methods target DNA, RNA or protein to reduce or to ablate gene...