Jacob E Corn
Overview
Explore the profile of Jacob E Corn including associated specialties, affiliations and a list of published articles.
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85
Citations
6792
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Recent Articles
1.
Muhar M, Farnung J, Cernakova M, Hofmann R, Henneberg L, Pfleiderer M, et al.
Nature
. 2025 Jan;
638(8050):519-527.
PMID: 39880951
During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins...
2.
Cullot G, Aird E, Schlapansky M, Yeh C, van de Venn L, Vykhlyantseva I, et al.
Nat Biotechnol
. 2024 Nov;
PMID: 39604565
The DNA-PKcs inhibitor AZD7648 enhances CRISPR-Cas9-directed homology-directed repair efficiencies, with potential for clinical utility, but its possible on-target consequences are unknown. We found that genome editing with AZD7648 causes frequent...
3.
Umhoefer J, Arce M, Whalen S, Dajani R, Goudy L, Kasinathan S, et al.
bioRxiv
. 2024 Sep;
PMID: 39282425
FOXP3 is a lineage-defining transcription factor (TF) for immune-suppressive regulatory T cells (Tregs). While mice exclusively express FOXP3 in Tregs, humans also transiently express FOXP3 in stimulated conventional CD4+ T...
4.
Baldwin J, Heuser-Loy C, Saha T, Schelker R, Slavkovic-Lukic D, Strieder N, et al.
Cell
. 2024 Sep;
187(23):6614-6630.e21.
PMID: 39276774
Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies. Here, we describe an innovative platform to supply exogenous mitochondria to T cells, overcoming...
5.
Karasu M, Toufektchan E, Chen Y, Albertelli A, Cullot G, Maciejowski J, et al.
Nat Biotechnol
. 2024 Aug;
PMID: 39134754
CRISPR-Cas9-mediated homology-directed repair (HDR) can introduce desired mutations at targeted genomic sites, but achieving high efficiencies is a major hurdle in many cell types, including cells deficient in DNA repair...
6.
Karasu M, Jahnke L, Joseph B, Amerzhanova Y, Mironov A, Shu X, et al.
Mol Cell
. 2024 Jul;
84(14):2634-2647.e9.
PMID: 38964321
DNA repair is directly performed by hundreds of core factors and indirectly regulated by thousands of others. We massively expanded a CRISPR inhibition and Cas9-editing screening system to discover factors...
7.
Mowery C, Freimer J, Chen Z, Casani-Galdon S, Umhoefer J, Arce M, et al.
Nat Genet
. 2024 May;
56(6):1156-1167.
PMID: 38811842
Cis-regulatory elements (CREs) interact with trans regulators to orchestrate gene expression, but how transcriptional regulation is coordinated in multi-gene loci has not been experimentally defined. We sought to characterize the...
8.
Marone R, Landmann E, Devaux A, Lepore R, Seyres D, Zuin J, et al.
J Exp Med
. 2023 Sep;
220(12).
PMID: 37773046
Targeted eradication of transformed or otherwise dysregulated cells using monoclonal antibodies (mAb), antibody-drug conjugates (ADC), T cell engagers (TCE), or chimeric antigen receptor (CAR) cells is very effective for hematologic...
9.
Boontanrart M, Machler E, Ponta S, Nelis J, Preiano V, Corn J
Elife
. 2023 Jun;
12.
PMID: 37265399
The β-hemoglobinopathies, such as sickle cell disease and β-thalassemia, are one of the most common genetic diseases worldwide and are caused by mutations affecting the structure or production of β-globin...
10.
Farnung J, Muhar M, Liang J, Tolmachova K, Benoit R, Corn J, et al.
ACS Cent Sci
. 2023 May;
9(5):1025-1034.
PMID: 37252361
Macroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy are often achieved through the presence of short peptide sequences called LC3 interacting regions...