Matthias Gromeier
Overview
Explore the profile of Matthias Gromeier including associated specialties, affiliations and a list of published articles.
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79
Citations
2495
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Recent Articles
1.
Thompson E, Kang K, Stevenson K, Zhang H, Gromeier M, Ashley D, et al.
Transl Oncol
. 2024 Jan;
40:101875.
PMID: 38183802
HSV G207, a double-stranded, DNA virus, and the polio:rhinovirus chimera, PVSRIPO, a single positive-strand RNA virus, are viral immunotherapies being used to treat pediatric malignant brain tumors in clinical trials....
2.
Dobrikov M, Dobrikova E, Nardone-White D, McKay Z, Brown M, Gromeier M
mBio
. 2023 Nov;
14(6):e0191523.
PMID: 37962360
Multiple pattern recognition receptors sense vRNAs and initiate downstream innate signaling: endosomal Toll-like receptors (TLRs) 3, 7, and 8 and cytoplasmic RIG-I-like receptors (RLRs) RIG-I, and MDA5. They engage distinct...
3.
Brown M, Beasley G, McKay Z, Yang Y, Desjardins A, Randazzo D, et al.
J Immunother Cancer
. 2023 Apr;
11(4).
PMID: 37072349
Background: Antitumor mechanisms of CD4 T cells remain crudely defined, and means to effectively harness CD4 T-cell help for cancer immunotherapy are lacking. Pre-existing memory CD4 T cells hold potential...
4.
Thompson E, Landi D, Brown M, Friedman H, McLendon R, Herndon 2nd J, et al.
Lancet Child Adolesc Health
. 2023 Apr;
7(7):471-478.
PMID: 37004712
Background: Outcomes of recurrent paediatric high-grade glioma are poor, with a median overall survival of less than 6 months. Viral immunotherapy, such as the polio-rhinovirus chimera lerapolturev, is a novel...
5.
Yang Y, Brown M, Zhang G, Stevenson K, Mohme M, Kornahrens R, et al.
Neuro Oncol
. 2023 Mar;
25(9):1631-1643.
PMID: 36864784
Background: Malignant gliomas commandeer dense inflammatory infiltrates with glioma-associated macrophages and microglia (GAMM) promoting immune suppression, evasion, and tumor progression. Like all cells in the mononuclear phagocytic system, GAMM constitutively...
6.
Li S, McLendon R, Sankey E, Kornahrens R, Lyne A, Cavalli F, et al.
Clin Transl Oncol
. 2022 Oct;
25(3):696-705.
PMID: 36301489
Background: Medulloblastoma is the most common pediatric malignant brain tumor, consisting of four molecular subgroups (WNT, SHH, Group 3, Group 4) and 12 subtypes. Expression of the cell surface poliovirus...
7.
Beasley G, Brown M, Farrow N, Landa K, Al-Rohil R, Selim M, et al.
J Immunother Cancer
. 2022 Sep;
10(9).
PMID: 36175036
Background: We previously reported results from a phase 1 study testing intratumoral recombinant poliovirus, lerapolturev, in 12 melanoma patients. All 12 patients received anti-PD-1 systemic therapy before lerapolturev, and 11...
8.
Dobrikov M, Dobrikova E, McKay Z, Kastan J, Brown M, Gromeier M
mBio
. 2022 Jun;
13(3):e0085422.
PMID: 35652592
For RNA virus families except , viral RNA sensing includes Toll-like receptors and/or RIG-I. Picornavirus RNAs, whose 5' termini are shielded by a genome-linked protein, are predominately recognized by MDA5....
9.
Low J, Chandramohan V, Bowie M, Brown M, Waitkus M, Briley A, et al.
Cancer Cell
. 2022 Apr;
40(5):439-440.
PMID: 35487217
No abstract available.
10.
Beasley G, Nair S, Farrow N, Landa K, Selim M, Wiggs C, et al.
J Immunother Cancer
. 2021 Apr;
9(4).
PMID: 33875611
Background: While programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) antagonists have improved the prognosis for many patients with melanoma, around 60% fail therapy. PVSRIPO is a...