Matthias Gromeier
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Explore the profile of Matthias Gromeier including associated specialties, affiliations and a list of published articles.
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79
Citations
2495
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Recent Articles
11.
Kastan J, Tremblay M, Brown M, Trimarco J, Dobrikova E, Dobrikov M, et al.
mBio
. 2021 Apr;
12(2).
PMID: 33849973
Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation. Here, we report that EV 2A proteases cleave all three members of the YTHDF protein family,...
12.
Brown M, Mosaheb M, Mohme M, McKay Z, Holl E, Kastan J, et al.
Nat Commun
. 2021 Mar;
12(1):1858.
PMID: 33767151
Activating intra-tumor innate immunity might enhance tumor immune surveillance. Virotherapy is proposed to achieve tumor cell killing, while indirectly activating innate immunity. Here, we report that recombinant poliovirus therapy primarily...
13.
McKay Z, Brown M, Gromeier M
J Immunol
. 2021 Jan;
206(6):1385-1394.
PMID: 33504618
Crosstalk between costimulatory and coinhibitory ligands are a prominent node of immune cell regulation. Mounting evidence points toward a critical role for CD155, the poliovirus receptor, in suppressing T cell...
14.
Gromeier M, Brown M, Zhang G, Lin X, Chen Y, Wei Z, et al.
Nat Commun
. 2021 Jan;
12(1):352.
PMID: 33441554
Several immunotherapy clinical trials in recurrent glioblastoma have reported long-term survival benefits in 10-20% of patients. Here we perform genomic analysis of tumor tissue from recurrent WHO grade IV glioblastoma...
15.
Mosaheb M, Brown M, Dobrikova E, Dobrikov M, Gromeier M
Curr Opin Virol
. 2020 Aug;
44:73-80.
PMID: 32771959
Dendritic cells (DCs) are pivotal stimulators of T cell responses. They provide essential signals (epitope presentation, proinflammatory cytokines, co-stimulation) to T cells and prime adaptive immunity. Therefore, they are paramount...
16.
Kastan J, Dobrikova E, Bryant J, Gromeier M
Sci Adv
. 2020 Jun;
6(23):eaba0745.
PMID: 32537501
Eukaryotic protein synthesis control at multiple levels allows for dynamic, selective responses to diverse conditions, but spatial organization of translation initiation machinery as a regulatory principle has remained largely unexplored....
17.
Mosaheb M, Dobrikova E, Brown M, Yang Y, Cable J, Okada H, et al.
Nat Commun
. 2020 Jan;
11(1):524.
PMID: 31988324
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as...
18.
Chandramohan V, Bao X, Yu X, Parker S, McDowall C, Yu Y, et al.
J Immunother Cancer
. 2019 May;
7(1):142.
PMID: 31142380
Background: D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in glioblastoma. In addition to inherent tumoricidal activity, immunotoxins...
19.
Yu X, Dobrikov M, Keir S, Gromeier M, Pastan I, Reisfeld R, et al.
PLoS One
. 2019 Jan;
14(1):e0210608.
PMID: 30625226
Standard treatment, unfortunately, yields a poor prognosis for patients with primary or metastatic cancers in the central nervous system, indicating a necessity for novel therapeutic agents. Immunotoxins (ITs) are a...
20.
Dobrikov M, Dobrikova E, Gromeier M
Mol Cell Biol
. 2018 Jul;
38(19).
PMID: 30012864
The receptor for activated C kinase (RACK1), a conserved constituent of eukaryotic ribosomes, mediates phosphorylation of eukaryotic initiation factor 4G1(S1093) [eIF4G1(S1093)] and eIF3a(S1364) by protein kinase C βII (PKCβII) (M....