Matthias E Werner
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Explore the profile of Matthias E Werner including associated specialties, affiliations and a list of published articles.
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11
Citations
730
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Recent Articles
1.
Withers S, Simpson L, Fattah S, Werner M, Heagerty A
Cardiovasc Res
. 2013 Oct;
101(1):130-7.
PMID: 24095868
Aim: The aim of this study was to investigate the role of cGMP-dependent protein kinase (PKG) in mediating the anticontractile function of perivascular adipose tissue (PVAT) and whether its activation...
2.
Lynch F, Withers S, Yao Z, Werner M, Edwards G, Weston A, et al.
Am J Physiol Heart Circ Physiol
. 2013 Jan;
304(6):H786-95.
PMID: 23292715
This study aims to identify the potential mechanisms by which perivascular adipose tissue (PVAT) reduces tone in small arteries. Small mesenteric arteries from wild-type and large-conductance Ca(2+)-activated K(+) (BKCa) channel...
3.
Joshi S, Nelson M, Werner M
Br J Pharmacol
. 2011 Jul;
165(2):455-66.
PMID: 21718308
Background And Purpose: Relaxation of corpus cavernosum smooth muscle (CCSM) is induced by NO. NO promotes the formation of cGMP, which activates cGMP-dependent protein kinase I (PKGI). The large conductance...
4.
Hill-Eubanks D, Werner M, Heppner T, Nelson M
Cold Spring Harb Perspect Biol
. 2011 Jun;
3(9):a004549.
PMID: 21709182
Changes in intracellular Ca(2+) are central to the function of smooth muscle, which lines the walls of all hollow organs. These changes take a variety of forms, from sustained, cell-wide...
5.
Hill-Eubanks D, Werner M, Nelson M
J Gen Physiol
. 2010 Jul;
136(2):149-54.
PMID: 20660658
No abstract available.
6.
Heppner T, Werner M, Nausch B, Vial C, Evans R, Nelson M
J Physiol
. 2009 Sep;
587(Pt 21):5275-88.
PMID: 19736301
Contraction of urinary bladder smooth muscle (UBSM) is caused by the release of ATP and ACh from parasympathetic nerves. Although both purinergic and muscarinic pathways are important to contraction, their...
7.
Werner M, Meredith A, Aldrich R, Nelson M
Am J Physiol Regul Integr Comp Physiol
. 2008 May;
295(1):R181-8.
PMID: 18480246
Erectile dysfunction (ED) can be elicited by a variety of pathogenic factors, particularly impaired formation of and responsiveness to nitric oxide (NO) and the downstream effectors soluble guanylate cyclase (sGC)...
8.
Werner M, Knorn A, Meredith A, Aldrich R, Nelson M
Am J Physiol Regul Integr Comp Physiol
. 2006 Aug;
292(1):R616-24.
PMID: 16931654
In the urinary bladder, contractions of the detrusor muscle and urine voiding are induced by the neurotransmitters ACh and ATP, released from parasympathetic nerves. Activation of K(+) channels, in particular...
9.
Ledoux J, Werner M, Brayden J, Nelson M
Physiology (Bethesda)
. 2006 Jan;
21:69-78.
PMID: 16443824
Different calcium signals in the endothelium and smooth muscle target different types of Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium signals and targets represent multilayered opportunities for...
10.
Werner M, Zvara P, Meredith A, Aldrich R, Nelson M
J Physiol
. 2005 Jul;
567(Pt 2):545-56.
PMID: 16020453
Penile erection is dependent on the nitric oxide (NO)/cGMP-dependent protein kinase I (PKGI) pathway. One important target of PKGI in smooth muscle is the large-conductance, calcium-activated potassium (BK) channel, which...