Matthias C Truttmann
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Explore the profile of Matthias C Truttmann including associated specialties, affiliations and a list of published articles.
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33
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1183
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Recent Articles
1.
Chatterjee B, Alam M, Chakravorty A, Lacy S, Giblin W, Rech J, et al.
ACS Chem Biol
. 2025 Mar;
PMID: 40036289
The AMP transferase, FICD, is an emerging drug target fine-tuning stress signaling in the endoplasmic reticulum (ER). FICD is a bifunctional enzyme, catalyzing both AMP addition (AMPylation) and removal (deAMPylation)...
2.
Urban N, Lacy S, Van Pelt K, Abdon B, Mattiola Z, Klaiss A, et al.
bioRxiv
. 2025 Jan;
PMID: 39868301
Cellular systems that govern protein folding rely on a delicate balance of functional redundancy and diversification to maintain protein homeostasis (proteostasis). Here, we use to demonstrate how both overlapping and...
3.
Van Pelt K, Truttmann M
bioRxiv
. 2024 Dec;
PMID: 39651313
Targeted regulation of cellular proteostasis machinery represents a promising strategy for the attenuation of pathological protein aggregation. Recent work suggests that the unfolded protein response in the endoplasmic reticulum (UPR...
4.
Hernandez-Lima M, Seo B, Urban N, Truttmann M
bioRxiv
. 2024 Oct;
PMID: 39416137
The ability of the nervous system to initiate intricate goal-directed behaviors in response to environmental stimuli is essential for metazoan survival. In this study, we demonstrate that the nematode perceives...
5.
Chatterjee B, Alam M, Chakravorty A, Lacy S, Rech J, Brooks 3rd C, et al.
bioRxiv
. 2024 Jul;
PMID: 39071275
The AMP transferase, FICD, is an emerging drug target finetuning stress signaling in the endoplasmic reticulum (ER). FICD is a bi-functional enzyme, catalyzing both AMP addition (AMPylation) and removal (deAMPylation)...
6.
Ray P, Jaiswal S, Ferrer-Torres D, Wang Z, Nancarrow D, Curtin M, et al.
Mol Cancer Res
. 2024 Jul;
22(11):996-1010.
PMID: 39018356
Frequent (>70%) TP53 mutations often promote its protein stabilization, driving esophageal adenocarcinoma (EAC) development linked to poor survival and therapy resistance. We previously reported that during Barrett's esophagus progression to...
7.
Lacy S, Taubitz R, Urban N, Turowski S, Smith E, Helms A, et al.
bioRxiv
. 2024 Jun;
PMID: 38853840
Cardiomyocytes require the HSP70 chaperone BiP to maintain proteostasis in the endoplasmic reticulum (ER) following cardiac stress. The adenylyl transferase (AMPylase) FICD is increasingly recognized to regulate BiP activity through...
8.
Porter C, Tabler S, Choi S, Truttmann M
Sci Rep
. 2024 Jun;
14(1):12688.
PMID: 38830987
Comprehensive characterization of protein networks in mounted brain tissue represents a major challenge in brain and neurodegenerative disease research. In this study, we develop a simple staining method, called TSWIFT,...
9.
Bourboulia D, Blair L, Clark M, Edkins A, Hightower L, Mollapour M, et al.
Cell Stress Chaperones
. 2024 Feb;
29(1):113-115.
PMID: 38309687
No abstract available.
10.
Porter C, Truttmann M
bioRxiv
. 2023 Oct;
PMID: 37786703
Comprehensive characterization of protein networks in mounted brain tissue represents a major challenge in brain and neurodegenerative disease research. In this study, we develop a simple staining method, called TSWIFT,...