Matthias Altmeyer
Overview
Explore the profile of Matthias Altmeyer including associated specialties, affiliations and a list of published articles.
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71
Citations
4350
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Recent Articles
11.
Balbo Pogliano C, Ceppi I, Giovannini S, Petroulaki V, Palmer N, Uliana F, et al.
Sci Adv
. 2022 Feb;
8(5):eabk0221.
PMID: 35119917
Bloom's syndrome is caused by inactivation of the BLM helicase, which functions with TOP3A and RMI1-2 (BTR complex) to dissolve recombination intermediates and avoid somatic crossing-over. We show here that...
12.
Yilmaz D, Furst A, Meaburn K, Lezaja A, Wen Y, Altmeyer M, et al.
Nature
. 2021 Dec;
600(7890):748-753.
PMID: 34853474
Centromeric integrity is key for proper chromosome segregation during cell division. Centromeres have unique chromatin features that are essential for centromere maintenance. Although they are intrinsically fragile and represent hotspots...
13.
Panagopoulos A, Altmeyer M
EMBO Rep
. 2021 Nov;
22(12):e54116.
PMID: 34726332
The tumor suppressor protein BRCA1 plays an important role in DNA repair by homologous recombination. Despite being encoded by the first familial breast and ovarian cancer gene identified, how BRCA1...
14.
Porro A, Mohiuddin M, Zurfluh C, Spegg V, Dai J, Iehl F, et al.
Sci Adv
. 2021 Jul;
7(31).
PMID: 34330701
FAN1, a DNA structure-specific nuclease, interacts with MLH1, but the repair pathways in which this complex acts are unknown. FAN1 processes DNA interstrand crosslinks (ICLs) and FAN1 variants are modifiers...
15.
Luscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, et al.
FEBS J
. 2021 Jul;
289(23):7399-7410.
PMID: 34323016
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in...
16.
Spegg V, Altmeyer M
DNA Repair (Amst)
. 2021 Jul;
106:103179.
PMID: 34311273
Protein recruitment to DNA break sites is an integral part of the DNA damage response (DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as well...
17.
Lezaja A, Panagopoulos A, Wen Y, Carvalho E, Imhof R, Altmeyer M
Nat Commun
. 2021 Jun;
12(1):3827.
PMID: 34158486
The paradigm that checkpoints halt cell cycle progression for genome repair has been challenged by the recent discovery of heritable DNA lesions escaping checkpoint control. How such inherited lesions affect...
18.
Parnandi N, Rendo V, Cui G, Botuyan M, Remisova M, Nguyen H, et al.
Mol Cell
. 2021 May;
81(12):2583-2595.e6.
PMID: 33961797
53BP1 influences genome stability via two independent mechanisms: (1) regulating DNA double-strand break (DSB) repair and (2) enhancing p53 activity. We discovered a protein, Tudor-interacting repair regulator (TIRR), that associates...
19.
AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
Ghodke I, Remisova M, Furst A, Kilic S, Reina-San-Martin B, Poetsch A, et al.
Mol Cell
. 2021 May;
81(12):2596-2610.e7.
PMID: 33961796
p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53 signaling. Although 53BP1's function is well established in DNA double-strand break repair, how its role in p53 signaling...
20.
Michelena J, Pellegrino S, Spegg V, Altmeyer M
Life Sci Alliance
. 2021 Apr;
4(6).
PMID: 33811064
DNA double-strand breaks can be repaired by non-homologous end-joining or homologous recombination. Which pathway is used depends on the balance between the tumor suppressors 53BP1 and BRCA1 and on the...