Matthew Tegtmeyer
Overview
Explore the profile of Matthew Tegtmeyer including associated specialties, affiliations and a list of published articles.
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13
Citations
142
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Recent Articles
1.
Vartiainen E, Liyanage D, Mazureac I, Battaglia R, Tegtmeyer M, He J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975161
Astrocytes participate in neuronal synaptic programs that are enriched for genetic associations in schizophrenia and autism spectrum disorders (ASD). To better understand how these co-regulated cellular programs are induced during...
2.
Bunting E, Donaldson J, Cumming S, Olive J, Broom E, Miclaus M, et al.
Sci Transl Med
. 2025 Feb;
17(785):eadn4600.
PMID: 39937881
Expanded CAG alleles in the huntingtin () gene that cause the neurodegenerative disorder Huntington's disease (HD) are genetically unstable and continue to expand somatically throughout life, driving HD onset and...
3.
Tegtmeyer M, Liyanage D, Han Y, Hebert K, Pei R, Way G, et al.
bioRxiv
. 2024 Nov;
PMID: 39605350
Neuropsychiatric conditions pose substantial challenges for therapeutic development due to their complex and poorly understood underlying mechanisms. High-throughput, unbiased phenotypic assays present a promising path for advancing therapeutic discovery, especially...
4.
Anton-Bolanos N, Faravelli I, Faits T, Andreadis S, Kastli R, Trattaro S, et al.
Nature
. 2024 Jun;
631(8019):142-149.
PMID: 38926573
Interindividual genetic variation affects the susceptibility to and progression of many diseases. However, efforts to study how individual human brains differ in normal development and disease phenotypes are limited by...
5.
Xu Y, Fleming S, Tegtmeyer M, McCarroll S, Babadi M
bioRxiv
. 2024 Apr;
PMID: 38558987
Single-cell transcriptomics, in conjunction with genetic and compound perturbations, offers a robust approach for exploring cellular behaviors in diverse contexts. Such experiments allow uncovering cell-state-specific responses to perturbations, a crucial...
6.
Tegtmeyer M, Arora J, Asgari S, Cimini B, Nadig A, Peirent E, et al.
Nat Commun
. 2024 Jan;
15(1):347.
PMID: 38184653
The morphology of cells is dynamic and mediated by genetic and environmental factors. Characterizing how genetic variation impacts cell morphology can provide an important link between disease association and cellular...
7.
Lakes Y, Moye S, Mo J, Tegtmeyer M, Nehme R, Charlton M, et al.
Cell Rep Med
. 2023 Dec;
4(12):101309.
PMID: 38086379
Cutaneous neurofibromas (cNFs) are tumors that develop in more than 99% of individuals with neurofibromatosis type 1 (NF1). They develop in the dermis and can number in the thousands. cNFs...
8.
Gazestani V, Kamath T, Nadaf N, Dougalis A, Burris S, Rooney B, et al.
Cell
. 2023 Sep;
186(20):4438-4453.e23.
PMID: 37774681
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human postmortem samples and model organisms. Here, we generated a single-nucleus atlas from a rare cohort of cortical biopsies from...
9.
Berryer M, Tegtmeyer M, Binan L, Valakh V, Nathanson A, Trendafilova D, et al.
iScience
. 2023 Aug;
26(7):106995.
PMID: 37534135
Emerging evidence of species divergent features of astrocytes coupled with the relative inaccessibility of human brain tissue underscore the utility of human pluripotent stem cell (hPSC) technologies for the generation...
10.
Gazestani V, Kamath T, Nadaf N, Burris S, Rooney B, Junkkari A, et al.
bioRxiv
. 2023 Jun;
PMID: 37333365
Cellular perturbations underlying Alzheimer's disease are primarily studied in human postmortem samples and model organisms. Here we generated a single-nucleus atlas from a rare cohort of cortical biopsies from living...