Ralda Nehme
Overview
Explore the profile of Ralda Nehme including associated specialties, affiliations and a list of published articles.
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25
Citations
421
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Recent Articles
1.
Binan L, Jiang A, Danquah S, Valakh V, Simonton B, Bezney J, et al.
Cell
. 2025 Mar;
PMID: 40081369
Pooled optical screens have enabled the study of cellular interactions, morphology, or dynamics at massive scale, but they have not yet leveraged the power of highly plexed single-cell resolved transcriptomic...
2.
Kang B, Murphy M, Ng C, Leventhal M, Huynh N, Im E, et al.
bioRxiv
. 2025 Mar;
PMID: 40027702
Genomic screens and GWAS are powerful tools for identifying disease-modifying genes, but it is often challenging to understand the pathways by which these genes function. Here, we take an integrated...
3.
Vartiainen E, Liyanage D, Mazureac I, Battaglia R, Tegtmeyer M, He J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975161
Astrocytes participate in neuronal synaptic programs that are enriched for genetic associations in schizophrenia and autism spectrum disorders (ASD). To better understand how these co-regulated cellular programs are induced during...
4.
Di Re J, Marini M, Hussain S, Singh A, Venkatesh A, Alshammari M, et al.
Mol Psychiatry
. 2025 Feb;
PMID: 39920295
Schizophrenia (SCZ) is a complex psychiatric disorder with unclear biological mechanisms. Spectrins, cytoskeletal proteins linked to neurodevelopmental disorders, are regulated by the AKT/GSK3 pathway, which is implicated in SCZ. However,...
5.
Wang B, Ma T, Chen T, Nguyen T, Crouse E, Fleming S, et al.
Npj Imaging
. 2024 Dec;
2(1):51.
PMID: 39649342
Voltage imaging is a powerful technique for studying neuronal activity, but its effectiveness is often constrained by low signal-to-noise ratios (SNR). Traditional denoising methods, such as matrix factorization, impose rigid...
6.
Tegtmeyer M, Liyanage D, Han Y, Hebert K, Pei R, Way G, et al.
bioRxiv
. 2024 Nov;
PMID: 39605350
Neuropsychiatric conditions pose substantial challenges for therapeutic development due to their complex and poorly understood underlying mechanisms. High-throughput, unbiased phenotypic assays present a promising path for advancing therapeutic discovery, especially...
7.
Anton-Bolanos N, Faravelli I, Faits T, Andreadis S, Kastli R, Trattaro S, et al.
Nature
. 2024 Jun;
631(8019):142-149.
PMID: 38926573
Interindividual genetic variation affects the susceptibility to and progression of many diseases. However, efforts to study how individual human brains differ in normal development and disease phenotypes are limited by...
8.
Nehme R, Pietilainen O, Barrett L
Trends Neurosci
. 2024 Jun;
47(7):491-505.
PMID: 38897852
While many core biological processes are conserved across species, the human brain has evolved with unique capacities. Current understanding of the neurobiological mechanisms that endow human traits as well as...
9.
Wang B, Ma T, Chen T, Nguyen T, Crouse E, Fleming S, et al.
bioRxiv
. 2024 Apr;
PMID: 38659950
Voltage imaging enables high-throughput investigation of neuronal activity, yet its utility is often constrained by a low signal-to-noise ratio (SNR). Conventional denoising algorithms, such as those based on matrix factorization,...
10.
Leventhal M, Zanella C, Kang B, Peng J, Gritsch D, Liao Z, et al.
bioRxiv
. 2024 Apr;
PMID: 38559190
Despite years of intense investigation, the mechanisms underlying neuronal death in Alzheimer's disease, the most common neurodegenerative disorder, remain incompletely understood. To define relevant pathways, we integrated the results of...