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Matthew Tegtmeyer

Explore the profile of Matthew Tegtmeyer including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 142
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Recent Articles
11.
Wells M, Nemesh J, Ghosh S, Mitchell J, Salick M, Mello C, et al.
Cell Stem Cell . 2023 Feb; 30(3):312-332.e13. PMID: 36796362
Human genome variation contributes to diversity in neurodevelopmental outcomes and vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require scalable approaches. Here, we describe a "cell village" experimental platform...
12.
Pietilainen O, Trehan A, Meyer D, Mitchell J, Tegtmeyer M, Valakh V, et al.
Cell Rep . 2023 Jan; 42(1):111988. PMID: 36640364
The maturation of neurons and the development of synapses, although emblematic of neurons, also relies on interactions with astrocytes and other glia. Here, to study the role of glia-neuron interactions,...
13.
Rapino F, Natoli T, Limone F, OConnor E, Blank J, Tegtmeyer M, et al.
Stem Cell Reports . 2022 Dec; 18(1):237-253. PMID: 36563689
In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that...
14.
Nehme R, Pietilainen O, Artomov M, Tegtmeyer M, Valakh V, Lehtonen L, et al.
Nat Commun . 2022 Jun; 13(1):3690. PMID: 35760976
It is unclear how the 22q11.2 deletion predisposes to psychiatric disease. To study this, we generated induced pluripotent stem cells from deletion carriers and controls and utilized CRISPR/Cas9 to introduce...
15.
Tegtmeyer M, Nehme R
J Mol Biol . 2021 Sep; 434(3):167221. PMID: 34474087
Since their discovery 15 years ago, human pluripotent stem cell (hPSC) technologies have begun to revolutionize science and medicine, rapidly expanding beyond investigative research to drug discovery and development. Efforts...