Matthew P Bubak
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Explore the profile of Matthew P Bubak including associated specialties, affiliations and a list of published articles.
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14
Citations
68
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Recent Articles
1.
Bubak M, Davidyan A, OReilly C, Mondal S, Keast J, Doidge S, et al.
Aging Cell
. 2024 Jun;
23(9):e14235.
PMID: 38923664
The rationale for the use of metformin as a treatment to slow aging was largely based on data collected from metabolically unhealthy individuals. For healthspan extension metformin will also be...
2.
Milan M, Brown J, OReilly C, Bubak M, Negri S, Balasubramanian P, et al.
Redox Biol
. 2024 May;
73:103189.
PMID: 38788541
Age-related endothelial dysfunction is a pivotal factor in the development of cardiovascular diseases, stemming, at least in part, from mitochondrial dysfunction and a consequential increase in oxidative stress. These alterations...
3.
Bubak M, Davidyan A, OReilly C, Mondal S, Keast J, Doidge S, et al.
bioRxiv
. 2024 Mar;
PMID: 38496648
The rationale for the use of metformin as a treatment to slow aging was largely based on data collected from metabolically unhealthy individuals. For healthspan extension metformin will also be...
4.
Bubak M, Mann S, Borowik A, Pranay A, Batushansky A, de Sousa Neto I, et al.
Am J Physiol Endocrinol Metab
. 2024 Jan;
326(3):E226-E244.
PMID: 38197793
17α-estradiol (17α-E2) is a naturally occurring nonfeminizing diastereomer of 17β-estradiol that has life span-extending effects in rodent models. To date, studies of the systemic and tissue-specific benefits of 17α-E2 have...
5.
Ansere V, Bubak M, Miller B, Freeman W
Rejuvenation Res
. 2023 Aug;
26(5):171-179.
PMID: 37551981
Experimental approaches such as Heterochronic Plasma Transfer (HPT) provide insights into the aging process and help identify the factors that impact aging, with the aim of developing anti-aging therapies. HPT...
6.
Bubak M, Mann S, Borowik A, Pranay A, Batushansky A, Ali Mondal S, et al.
bioRxiv
. 2023 Jul;
PMID: 37398463
Skeletal muscle has a central role in maintaining metabolic homeostasis. 17α-estradiol (17α-E2), a naturally-occurring non-feminizing diastereomer of 17β-estradiol that demonstrates efficacy for improving metabolic outcomes in male, but not female,...
7.
Ali Mondal S, Mann S, van der Linden C, Sathiaseelan R, Kamal M, Das S, et al.
Sci Rep
. 2023 Jun;
13(1):9841.
PMID: 37330610
Metabolic dysfunction underlies several chronic diseases. Dietary interventions can reverse metabolic declines and slow aging but remaining compliant is difficult. 17α-estradiol (17α-E2) treatment improves metabolic parameters and slows aging in...
8.
Ali Mondal S, Mann S, van der Linden C, Sathiaseelan R, Kamal M, Das S, et al.
bioRxiv
. 2023 Mar;
PMID: 36993459
Metabolic dysfunction underlies several chronic diseases. Dietary interventions can reverse metabolic declines and slow aging but remaining compliant is difficult. 17α-estradiol (17α-E2) treatment improves metabolic parameters and slows aging in...
9.
Borowik A, Davidyan A, Peelor 3rd F, Voloviceva E, Doidge S, Bubak M, et al.
Function (Oxf)
. 2022 Dec;
4(1):zqac059.
PMID: 36569816
The skeletal muscle research field generally accepts that nuclei in skeletal muscle fibers (ie, myonuclei) are post-mitotic and unable to proliferate. Because our deuterium oxide (DO) labeling studies showed DNA...
10.
Bubak M, Stout K, Tomtschik J, Peterson E, Cardozo C, Graham Z, et al.
Exp Physiol
. 2022 May;
107(8):800-806.
PMID: 35562322
New Findings: What is the central question of this study? Do Notch, Numb and Numb-like expression change in human skeletal muscle after exercise-induced muscle damage? What are the main finding...