Matthew K Gould
Overview
Explore the profile of Matthew K Gould including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
530
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Bachmaier S, Gould M, Polatoglou E, Omelianczyk R, Brennand A, Aloraini M, et al.
Front Cell Infect Microbiol
. 2023 Jul;
13:1204707.
PMID: 37475965
Cyclic AMP signalling in trypanosomes differs from most eukaryotes due to absence of known cAMP effectors and cAMP independence of PKA. We have previously identified four genes from a genome-wide...
2.
Rao S, Gould M, Noeske J, Saldivia M, Jumani R, Ng P, et al.
Science
. 2023 Jun;
380(6652):1349-1356.
PMID: 37384702
Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease and human African trypanosomiasis (HAT). Improved HAT treatments are available, but...
3.
Dickie E, Giordani F, Gould M, Maser P, Burri C, Mottram J, et al.
Trop Med Infect Dis
. 2020 Feb;
5(1).
PMID: 32092897
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease...
4.
Dewar C, MacGregor P, Cooper S, Gould M, Matthews K, Savill N, et al.
PLoS Pathog
. 2018 Jul;
14(7):e1007195.
PMID: 30020996
The sleeping sickness parasite Trypanosoma brucei has a complex life cycle, alternating between a mammalian host and the tsetse fly vector. A tightly controlled developmental programme ensures parasite transmission between...
5.
Eze A, Gould M, Munday J, Tagoe D, Stelmanis V, Schnaufer A, et al.
PLoS Negl Trop Dis
. 2016 Aug;
10(8):e0004791.
PMID: 27518185
Background: Isometamidium is the main prophylactic drug used to prevent the infection of livestock with trypanosomes that cause Animal African Trypanosomiasis. As well as the animal infective trypanosome species, livestock...
6.
Grewal J, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, et al.
J Biol Chem
. 2016 Mar;
291(18):9492-500.
PMID: 26940875
The structure of a C11 peptidase PmC11 from the gut bacterium, Parabacteroides merdae, has recently been determined, enabling the identification and characterization of a C11 orthologue, PNT1, in the parasitic...
7.
Gould M, Schnaufer A
Antimicrob Agents Chemother
. 2014 Feb;
58(5):2925-8.
PMID: 24550326
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast. To what extent this property relates to...
8.
Dean S, Gould M, Dewar C, Schnaufer A
Proc Natl Acad Sci U S A
. 2013 Aug;
110(36):14741-6.
PMID: 23959897
Viability of the tsetse fly-transmitted African trypanosome Trypanosoma brucei depends on maintenance and expression of its kinetoplast (kDNA), the mitochondrial genome of this parasite and a putative target for veterinary...
9.
Gould M, Bachmaier S, Ali J, Alsford S, Tagoe D, Munday J, et al.
Antimicrob Agents Chemother
. 2013 Jul;
57(10):4882-93.
PMID: 23877697
One of the most promising new targets for trypanocidal drugs to emerge in recent years is the cyclic AMP (cAMP) phosphodiesterase (PDE) activity encoded by TbrPDEB1 and TbrPDEB2. These genes...
10.
de Koning H, Gould M, Sterk G, Tenor H, Kunz S, Luginbuehl E, et al.
J Infect Dis
. 2012 Feb;
206(2):229-37.
PMID: 22291195
The development of drugs for neglected infectious diseases often uses parasite-specific enzymes as targets. We here demonstrate that parasite enzymes with highly conserved human homologs may represent a promising reservoir...