Jeremy C Mottram
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Explore the profile of Jeremy C Mottram including associated specialties, affiliations and a list of published articles.
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177
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11209
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Recent Articles
1.
Repoles B, Rodrigues Ferreira W, de Assis A, Mendes I, Morini F, Goncalves C, et al.
Mitochondrion
. 2025 Feb;
:102009.
PMID: 39993491
Although several proteins involved in DNA repair systems have been identified in the T. cruzi mitochondrion, limited information is available regarding the specific DNA repair mechanisms responsible for kinetoplast DNA...
2.
Corrales R, Vincent J, Crobu L, Neish R, Nepal B, Espeut J, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(3):e2415296122.
PMID: 39808657
Tubulin detyrosination has been implicated in various human disorders and is important for regulating microtubule dynamics. While in most organisms this modification is restricted to α-tubulin, in trypanosomatid parasites, it...
3.
Albuquerque-Wendt A, McCoy C, Neish R, Dobramysl U, Alagoz C, Beneke T, et al.
Nat Commun
. 2025 Jan;
16(1):299.
PMID: 39747086
For the protozoan parasite Leishmania, completion of its life cycle requires sequential adaptation of cellular physiology and nutrient scavenging mechanisms to the different environments of a sand fly alimentary tract...
4.
Burge R, Jameson K, Geoghegan V, Dowle A, Mottram J, Wilkinson A
Mol Biochem Parasitol
. 2024 Mar;
258:111619.
PMID: 38556171
In eukaryotic cells, molecular fate and cellular responses are shaped by multicomponent enzyme systems which reversibly attach ubiquitin and ubiquitin-like modifiers to target proteins. The extent of the ubiquitin proteasome...
5.
Myburgh E, Geoghegan V, Alves-Ferreira E, Nievas Y, Grewal J, Brown E, et al.
EMBO Rep
. 2024 Feb;
25(3):1075-1105.
PMID: 38396206
Leishmania parasites undergo differentiation between various proliferating and non-dividing forms to adapt to changing host environments. The mechanisms that link environmental cues with the parasite's developmental changes remain elusive. Here,...
6.
Saldivia M, Lima A, Mottram J
Trends Parasitol
. 2024 Feb;
40(3):211-213.
PMID: 38368155
The drug discovery pipeline for leishmaniasis and trypanosomiasis has been filling with novel chemical entities with known mechanisms of action. González et al. and Braillard et al. report a cytochrome...
7.
Russell C, Carter J, Borgia J, Bush J, Calderon F, Gabarro R, et al.
ACS Infect Dis
. 2023 Oct;
9(11):2340-2357.
PMID: 37906637
Leishmaniases are a collection of neglected tropical diseases caused by kinetoplastid parasites in the genus . Current chemotherapies are severely limited, and the need for new antileishmanials is of pressing...
8.
Black J, Klinger C, Lemgruber L, Dacks J, Mottram J, McCulloch R
J Eukaryot Microbiol
. 2023 Aug;
70(6):e12994.
PMID: 37548427
Selection and internalization of cargo via clathrin-mediated endocytosis requires adaptor protein complexes. One complex, AP-2, acts during cargo selection at the plasma membrane. African trypanosomes lack all components of the...
9.
Rao S, Gould M, Noeske J, Saldivia M, Jumani R, Ng P, et al.
Science
. 2023 Jun;
380(6652):1349-1356.
PMID: 37384702
Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease and human African trypanosomiasis (HAT). Improved HAT treatments are available, but...
10.
Romano P, Akematsu T, Besteiro S, Bindschedler A, Carruthers V, Chahine Z, et al.
Autophagy Rep
. 2023 Apr;
2(1).
PMID: 37064813
Pathogenic protists are a group of organisms responsible for causing a variety of human diseases including malaria, sleeping sickness, Chagas disease, leishmaniasis, and toxoplasmosis, among others. These diseases, which affect...