Matthew J Killeen
Overview
Explore the profile of Matthew J Killeen including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
220
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Recent Articles
1.
Killeen M, Linder M, Pontoniere P, Crea R
Drug Discov Today
. 2013 Nov;
19(4):373-8.
PMID: 24246683
Chronic inflammation has a key role in the pathogenesis of multiple diseases that represent major public health and financial concerns, including heart failure (HF), Alzheimer's disease (AD) and arthritis. Nuclear...
2.
Killeen M
Drug Discov Today
. 2009 Jun;
14(11-12):589-97.
PMID: 19508921
Following a series of high profile withdrawals from the market, the ability of medications to induce potentially fatal arrhythmias is a significant problem facing the pharmaceutical industry. Current preclinical cardiac...
3.
Killeen M
Expert Opin Drug Saf
. 2009 Jun;
8(3):249-52.
PMID: 19505259
Following the publication of a recent study, which linked antipsychotics to sudden cardiac death, the safety of both typical and atypical antipsychotics has once again been questioned. Sudden cardiac death...
4.
Hothi S, Thomas G, Killeen M, Grace A, Huang C
Pflugers Arch
. 2009 May;
458(5):819-35.
PMID: 19430811
KCNE1 encodes the beta-subunit of the slow component of the delayed rectifier K(+) current. The Jervell and Lange-Nielsen syndrome is characterized by sensorineural deafness, prolonged QT intervals, and ventricular arrhythmogenicity....
5.
Hothi S, Booth S, Sabir I, Killeen M, Simpson F, Zhang Y, et al.
Prog Biophys Mol Biol
. 2009 Apr;
98(2-3):267-80.
PMID: 19351517
The gain-of-function Scn5a+/DeltaKPQ mutation in the cardiac Na(+) channel causes human long QT type 3 syndrome (LQT3) associated with ventricular arrhythmogenesis. The K(ATP) channel-opener nicorandil (20muM) significantly reduced arrhythmic incidence...
6.
Zhang Y, Schwiening C, Killeen M, Zhang Y, Ma A, Lei M, et al.
Clin Exp Pharmacol Physiol
. 2009 Mar;
36(10):969-80.
PMID: 19298534
1. Intracellular Ca(2+) overload has been associated with established atrial arrhythmogenesis. The present experiments went on to correlate acute initiation of atrial arrhythmogenesis in Langendorff-perfused mouse hearts with changes in...
7.
Sabir I, Killeen M, Grace A, Huang C
Prog Biophys Mol Biol
. 2008 Dec;
98(2-3):208-18.
PMID: 19041335
Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common cause of mortality and a significant public health burden. Insights into the electrophysiological basis of such phenomena...
8.
Killeen M, Sabir I, Grace A, Huang C
Prog Biophys Mol Biol
. 2008 Nov;
98(2-3):219-29.
PMID: 19027779
Sudden cardiac death resulting from ventricular arrhythmogenesis is a leading cause of mortality in the developed world, accounting for up to 400,000 deaths per year in the US alone. Within...
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