Ian N Sabir
Overview
Explore the profile of Ian N Sabir including associated specialties, affiliations and a list of published articles.
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15
Citations
207
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Recent Articles
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2.
Matthews G, Guzadhur L, Sabir I, Grace A, Huang C
J Physiol
. 2013 Jul;
591(17):4167-88.
PMID: 23836691
Reductions in cardiac action potential wavelength, and the consequent wavebreak, have been implicated in arrhythmogenesis. Tachyarrhythmias are more common in the Brugada syndrome, particularly following pharmacological challenge, previously modelled using...
3.
Sabir I, Matthews G, Huang C
Postgrad Med J
. 2013 Feb;
89(1052):346-51.
PMID: 23404744
Atrial fibrillation, the commonest cardiac arrhythmia, predisposes to thrombus formation and consequently increases risk of ischaemic stroke. Recent years have seen approval of a number of novel oral anticoagulants. Nevertheless,...
4.
Sabir I, Ma N, Jones V, Goddard C, Zhang Y, Kalin A, et al.
Front Physiol
. 2011 Mar;
1:126.
PMID: 21423368
The relationship between alternans and arrhythmogenicity was studied in genetically modified murine hearts modeling catecholaminergic polymorphic ventricular tachycardia (CPVT) during Langendorff perfusion, before and after treatment with catecholamines and a...
5.
Kalin A, Usher-Smith J, Jones V, Huang C, Sabir I
Trends Cardiovasc Med
. 2010 Dec;
20(3):103-7.
PMID: 21130954
This review presents a simple trigger-substrate model of arrhythmogenesis and its application to the generation of reentrant ventricular arrhythmias. We demonstrate its broad applicability to the understanding of arrhythmic phenomena...
6.
Sabir I, Usher-Smith J, Huang C, Grace A
Prog Biophys Mol Biol
. 2009 Apr;
98(2-3):340-6.
PMID: 19351522
Recent advances in pharmacological and device-based therapies have provided a range of management options for patients at risk of sudden cardiac death (SCD). Since all such interventions come with their...
7.
Hothi S, Booth S, Sabir I, Killeen M, Simpson F, Zhang Y, et al.
Prog Biophys Mol Biol
. 2009 Apr;
98(2-3):267-80.
PMID: 19351517
The gain-of-function Scn5a+/DeltaKPQ mutation in the cardiac Na(+) channel causes human long QT type 3 syndrome (LQT3) associated with ventricular arrhythmogenesis. The K(ATP) channel-opener nicorandil (20muM) significantly reduced arrhythmic incidence...
8.
Sabir I, Killeen M, Grace A, Huang C
Prog Biophys Mol Biol
. 2008 Dec;
98(2-3):208-18.
PMID: 19041335
Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common cause of mortality and a significant public health burden. Insights into the electrophysiological basis of such phenomena...
9.
Killeen M, Sabir I, Grace A, Huang C
Prog Biophys Mol Biol
. 2008 Nov;
98(2-3):219-29.
PMID: 19027779
Sudden cardiac death resulting from ventricular arrhythmogenesis is a leading cause of mortality in the developed world, accounting for up to 400,000 deaths per year in the US alone. Within...
10.
Sabir I, Li L, Jones V, Goddard C, Grace A, Huang C
Pflugers Arch
. 2007 Sep;
455(4):637-51.
PMID: 17805561
The experiments investigated the applicability of two established criteria for arrhythmogenicity in Scn5a+/Delta and Scn5a+/- murine hearts modelling the congenital long QT syndrome type 3 (LQT3) and the Brugada syndrome...