Matthew J Harms
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Explore the profile of Matthew J Harms including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
587
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Recent Articles
1.
Oostveen R, Khera A, Kathiresan S, Stroes E, FitzGerald K, Harms M, et al.
Arterioscler Thromb Vasc Biol
. 2023 Jun;
43(7):1081-1092.
PMID: 37259866
There is overwhelming clinical and genetic evidence supporting the concept that low-density-lipoprotein cholesterol should be as low as possible for as long as possible in patients at very high cardiovascular...
2.
Li Q, Hagberg C, Silva Cascales H, Lang S, Hyvonen M, Salehzadeh F, et al.
Nat Med
. 2021 Oct;
27(11):1941-1953.
PMID: 34608330
Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an increase in both...
3.
Alexandersson I, Harms M, Boucher J
J Vis Exp
. 2020 Mar;
(156).
PMID: 32116300
White adipose tissue (WAT) dysregulation plays a central role in development of insulin resistance and type 2 diabetes (T2D). To develop new treatments for T2D, more physiologically relevant in vitro...
4.
Osinski V, Bauknight D, Dasa S, Harms M, Kroon T, Marshall M, et al.
Theranostics
. 2020 Jan;
10(2):585-601.
PMID: 31903139
Macrophages are important regulators of obesity-associated inflammation and PPARα and -γ agonism in macrophages has anti-inflammatory effects. In this study, we tested the efficacy with which liposomal delivery could target...
5.
Harms M, Li Q, Lee S, Zhang C, Kull B, Hallen S, et al.
Cell Rep
. 2019 Apr;
27(1):213-225.e5.
PMID: 30943403
White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes. We describe a...
6.
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity
Hagberg C, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina I, et al.
Cell Rep
. 2018 Sep;
24(10):2746-2756.e5.
PMID: 30184507
Adipocytes, once considered simple lipid-storing cells, are rapidly emerging as complex cells with many biologically diverse functions. A powerful high-throughput method for analyzing single cells is flow cytometry. Several groups...
7.
Shapira S, Lim H, Rajakumari S, Sakers A, Ishibashi J, Harms M, et al.
Genes Dev
. 2017 Apr;
31(7):660-673.
PMID: 28428261
The transcription factor early B-cell factor 2 (EBF2) is an essential mediator of brown adipocyte commitment and terminal differentiation. However, the mechanisms by which EBF2 regulates chromatin to activate brown...
8.
Kissig M, Ishibashi J, Harms M, Lim H, Stine R, Won K, et al.
EMBO J
. 2017 Apr;
36(11):1528-1542.
PMID: 28408438
Brown adipose has the potential to counteract obesity, and thus, identifying signaling pathways that regulate the activity of this tissue is of great clinical interest. PRDM16 is a transcription factor...
9.
Harms M, Lim H, Ho Y, Shapira S, Ishibashi J, Rajakumari S, et al.
Genes Dev
. 2015 Feb;
29(3):298-307.
PMID: 25644604
PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear. Through chromatin immunoprecipitation (ChIP) followed...
10.
Harms M, Ishibashi J, Wang W, Lim H, Goyama S, Sato T, et al.
Cell Metab
. 2014 Apr;
19(4):593-604.
PMID: 24703692
Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brown adipose...