Matthew H Todd
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Explore the profile of Matthew H Todd including associated specialties, affiliations and a list of published articles.
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70
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1051
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Recent Articles
41.
Yu M, Lim N, Ellis S, Nagase H, Triccas J, Rutledge P, et al.
ChemistryOpen
. 2014 Feb;
2(3):99-105.
PMID: 24551546
The synthesis and matrix metalloproteinase (MMP) inhibitory activity of a cyclam-marimastat conjugate and its metal complexes are described. The conjugate, synthesized with a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition ("click" reaction), contains...
42.
Patra M, Ingram K, Leonidova A, Pierroz V, Ferrari S, Robertson M, et al.
J Med Chem
. 2013 Nov;
56(22):9192-8.
PMID: 24219617
In vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel (PZQ) with the formula (η(6)-PZQ)Cr(CO)3 (1 and 2), by use of human liver microsomes....
43.
Masum H, Rao A, Good B, Todd M, Edwards A, Chan L, et al.
PLoS Comput Biol
. 2013 Oct;
9(9):e1003244.
PMID: 24086123
No abstract available.
44.
Robertson M, Ylioja P, Williamson A, Woelfle M, Robins M, Badiola K, et al.
Parasitology
. 2013 Aug;
141(1):148-57.
PMID: 23985301
Open science is a new concept for the practice of experimental laboratory-based research, such as drug discovery. The authors have recently gained experience in how to run such projects and...
45.
Tsang A, Ingram K, Keiser J, Hibbert D, Todd M
Org Biomol Chem
. 2013 Jul;
11(30):4921-4.
PMID: 23820826
A removable protecting group has been identified that allows the products of widely-used cross dehydrogenative couplings to be synthetically elaborated. The method can be used with enantiopure amines with no...
46.
Yu M, Yu Q, Rutledge P, Todd M
Chembiochem
. 2013 Jan;
14(2):224-9.
PMID: 23303717
We describe a new class of fluorescent reporter and its employment to visualize the biotin/avidin binding interaction. Derivatives of the azamacrocycle cyclam that contain a pendant naphthalimide dye are inherently...
47.
Ahamed M, Chan B, Jensen P, Todd M
PLoS One
. 2012 Oct;
7(10):e47224.
PMID: 23094038
We compare the results from the oxidation of two unusual "enediamide" motifs (3,4-dihydropyrazin-2(1H)-ones), where a double bond is flanked by two amides. In one case the oxidation led to a...
48.
Park S, Price J, Todd M
J Org Chem
. 2011 Dec;
77(2):949-55.
PMID: 22142205
We report the use of a previously intractable nucleophile, anisole, in an oxidative "cross-dehydrogenative coupling" (CDC) reaction with the cyclic ether isochroman, as well as derivatives of both components. Metal...
49.
Yu M, Price J, Jensen P, Lovitt C, Shelper T, Duffy S, et al.
Inorg Chem
. 2011 Nov;
50(24):12823-35.
PMID: 22111787
We describe the synthesis of cyclam metal complexes derivatized with amino acids or a tripeptide using a copper(I)-catalyzed Huisgen "click" reaction. The linker triazole formed during the synthesis plays an...
50.
Woelfle M, Seerden J, de Gooijer J, Pouwer K, Olliaro P, Todd M
PLoS Negl Trop Dis
. 2011 Sep;
5(9):e1260.
PMID: 21949890
Background: Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer...