Matthew H Todd
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Explore the profile of Matthew H Todd including associated specialties, affiliations and a list of published articles.
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1051
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Recent Articles
21.
Tse E, Korsik M, Todd M
Malar J
. 2019 Mar;
18(1):93.
PMID: 30902052
Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria prevention and...
22.
Guardia A, Baiget J, Cacho M, Perez A, Ortega-Guerra M, Nxumalo W, et al.
J Med Chem
. 2018 Nov;
61(24):11327-11340.
PMID: 30457865
Society urgently needs new, effective medicines for the treatment of tuberculosis. To kick-start the required hit-to-lead campaigns, the libraries of pharmaceutical companies have recently been evaluated for starting points. The...
23.
Munawar S, Windley M, Tse E, Todd M, Hill A, Vandenberg J, et al.
Front Pharmacol
. 2018 Oct;
9:1035.
PMID: 30333745
The hERG (human ether-a-go-go-related gene) encoded potassium ion (K) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major cause of potentially lethal ventricular...
24.
Lim W, Melse Y, Konings M, Phat Duong H, Eadie K, Laleu B, et al.
PLoS Negl Trop Dis
. 2018 Apr;
12(4):e0006437.
PMID: 29698504
Eumycetoma is a chronic infectious disease characterized by a large subcutaneous mass, often caused by the fungus Madurella mycetomatis. A combination of surgery and prolonged medication is needed to treat...
25.
Spain M, Wong J, Nagalingam G, Batten J, Hortle E, Oehlers S, et al.
J Med Chem
. 2018 Mar;
61(8):3595-3608.
PMID: 29558124
We recently reported the discovery of nontoxic cyclam-derived compounds that are active against drug-resistant Mycobacterium tuberculosis. In this paper we report exploration of the structure-activity relationship for this class of...
26.
Badiola K, Bird C, Brocklesby W, Casson J, Chapman R, Coles S, et al.
Chem Sci
. 2018 Jan;
6(3):1614-1629.
PMID: 29308130
Electronic Laboratory Notebooks (ELNs) are progressively replacing traditional paper books in both commercial research establishments and academic institutions. University researchers require specific features from ELNs, given the need to promote...
27.
Lau Y, Clegg J, Price J, Macquart R, Todd M, Rutledge P
Chemistry
. 2017 Oct;
24(7):1573-1585.
PMID: 29052259
Molecular switches have many potential applications in nanoscience and biomedicine. Transition metal complexes that can be switched from an inert, unreactive state to a catalytically active one by a simple...
28.
Tsang A, Hashmi A, Comba P, Kerscher M, Chan B, Todd M
Chemistry
. 2017 May;
23(39):9313-9318.
PMID: 28523850
The mechanism of cross-dehydrogenative coupling (CDC) reactions has been examined by experimental and computational methods. We provide a rationale for the ubiquity of the N-aryl group in these reactions. The...
29.
Balasegaram M, Kolb P, McKew J, Menon J, Olliaro P, Sablinski T, et al.
PLoS Med
. 2017 Apr;
14(4):e1002276.
PMID: 28419094
In an Essay, Matthew Todd and colleagues discuss an open source approach to drug development.
30.
Counsell A, Jones A, Todd M, Rutledge P
Beilstein J Org Chem
. 2017 Feb;
12:2457-2461.
PMID: 28144313
An efficient protocol for the direct synthesis of -tetraalkylated derivatives of the azamacrocycles cyclam and cyclen has been developed, using a partially miscible aqueous-organic solvent system with propargyl bromide, benzyl...