Matthew H Todd
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Explore the profile of Matthew H Todd including associated specialties, affiliations and a list of published articles.
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70
Citations
1051
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Recent Articles
11.
Tse E, Aithani L, Anderson M, Cardoso-Silva J, Cincilla G, Conduit G, et al.
J Med Chem
. 2021 Nov;
64(22):16450-16463.
PMID: 34748707
The Open Source Malaria (OSM) consortium is developing compounds that kill the human malaria parasite, , by targeting ATP4, an essential ion pump on the parasite surface. The structure of...
12.
Klug D, Idiris F, Blaskovich M, von Delft F, Dowson C, Kirchhelle C, et al.
Wellcome Open Res
. 2021 Jul;
6:146.
PMID: 34250265
There is an increasingly urgent need for new antibiotics, yet there is a significant and persistent economic problem when it comes to developing such medicines. The problem stems from the...
13.
Muratov E, Amaro R, Andrade C, Brown N, Ekins S, Fourches D, et al.
Chem Soc Rev
. 2021 Jul;
50(16):9121-9151.
PMID: 34212944
COVID-19 has resulted in huge numbers of infections and deaths worldwide and brought the most severe disruptions to societies and economies since the Great Depression. Massive experimental and computational research...
14.
Frei A, Zuegg J, Elliott A, Baker M, Braese S, Brown C, et al.
Chem Sci
. 2021 Jun;
11(17):4531.
PMID: 34122912
[This corrects the article DOI: 10.1039/C9SC06460E.].
15.
Counsell A, Yu M, Shi M, Jones A, Batten J, Turner P, et al.
Dalton Trans
. 2021 Feb;
50(11):3931-3942.
PMID: 33635937
The coordination chemistry of N-functionalised cyclam ligands has a rich history, yet cyclam derivatives with pendant alkynes are largely unexplored. This is despite the significant potential and burgeoning application of...
16.
Tse E, Klug D, Todd M
F1000Res
. 2020 Nov;
9:1043.
PMID: 33145011
In only a matter of months, the coronavirus disease of 2019 (COVID-19) has spread around the world. The global impact of the disease has caused significant and repeated calls for...
17.
Korsik M, Tse E, Smith D, Lewis W, Rutledge P, Todd M
J Org Chem
. 2020 Aug;
85(21):13438-13452.
PMID: 32786609
We have discovered and studied a -substitution reaction in a biologically important heterocyclic ring system. Conditions that favor the -substitution pathway were identified: the use of increased equivalents of the...
18.
Tse E, Houston S, Williams C, Savage G, Rendina L, Hallyburton I, et al.
J Med Chem
. 2020 Jul;
63(20):11585-11601.
PMID: 32678591
The replacement of one chemical motif with another that is broadly similar is a common method in medicinal chemistry to modulate the physical and biological properties of a molecule (i.e.,...
19.
Frei A, Zuegg J, Elliott A, Baker M, Braese S, Brown C, et al.
Chem Sci
. 2020 Mar;
11(10):2627-2639.
PMID: 32206266
There is a dire need for new antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of...
20.
Todd M
ChemMedChem
. 2019 Oct;
14(21):1804-1809.
PMID: 31612602
Six to swear by! Society needs effective and affordable medicines. We currently have at our disposal essentially one system to discover and develop drugs, and there are many areas where...