Matthew H Todd
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Explore the profile of Matthew H Todd including associated specialties, affiliations and a list of published articles.
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70
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1051
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Recent Articles
1.
Ghoshal A, Magalhaes A, Asressu K, Hossain M, Todd M, Willson T
Pharmaceuticals (Basel)
. 2024 Jul;
17(7).
PMID: 39065687
Optimized syntheses of ()-5-(2-ethoxyphenyl)--(3-(methylsulfonyl)allyl)-1-pyrazole-3-carboxamide (RA-0002034, ), a promising antiviral covalent cysteine protease inhibitor lead, were developed. The syntheses avoid the contamination of with the inactive cyclic dihydropyrazolo[1,5-]pyrazin-4(5)-one , which is...
2.
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, et al.
Nat Commun
. 2024 Jan;
15(1):937.
PMID: 38297033
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based...
3.
Klug D, Tse E, Silva D, Cao Y, Charman S, Chauhan J, et al.
ACS Infect Dis
. 2023 Nov;
9(12):2423-2435.
PMID: 37991879
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As...
4.
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, et al.
Res Sq
. 2023 Aug;
PMID: 37546892
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based...
5.
Dichiara M, Simpson Q, Quotadamo A, Jalani H, Huang A, Millard C, et al.
ACS Infect Dis
. 2023 Jul;
9(8):1470-1487.
PMID: 37417544
Leishmaniasis is a collection of diseases caused by more than 20 parasite species that manifest as either visceral, cutaneous, or mucocutaneous leishmaniasis. Despite the significant mortality and morbidity associated with...
6.
Ackloo S, Antolin A, Bartolome J, Beck H, Bullock A, Betz U, et al.
RSC Med Chem
. 2023 Jun;
14(6):1002-1011.
PMID: 37360399
Target 2035, an international federation of biomedical scientists from the public and private sectors, is leveraging 'open' principles to develop a pharmacological tool for every human protein. These tools are...
7.
Ball S, Adamson J, Sullivan M, Zimmermann M, Lo V, Sanz-Hernandez M, et al.
ACS Chem Neurosci
. 2022 Dec;
14(1):87-98.
PMID: 36542544
Alzheimer's disease is imposing a growing social and economic burden worldwide, and effective therapies are urgently required. One possible approach to modulation of the disease outcome is to use small...
8.
Ackloo S, Al-Awar R, Amaro R, Arrowsmith C, Azevedo H, Batey R, et al.
Nat Rev Chem
. 2022 Jul;
6(4):287-295.
PMID: 35783295
One aspirational goal of computational chemistry is to predict potent and drug-like binders for any protein, such that only those that bind are synthesized. In this Roadmap, we describe the...
9.
Muller S, Ackloo S, Al Chawaf A, Al-Lazikani B, Antolin A, Baell J, et al.
RSC Med Chem
. 2022 Feb;
13(1):13-21.
PMID: 35211674
Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. The challenge of translating the wealth of new...
10.
Lo A, Chen J, Murray V, Todd M, Hambley T
Dalton Trans
. 2021 Nov;
50(48):17945-17952.
PMID: 34842878
Complexes incorporating a threading anthraquinone intercalator with pyrrole lexitropsin and platinum(II) moieties attached were developed with the goal of generating novel DNA binding modes, including the targeting of AT-rich regions...